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Effects of different energy density low-level laser therapies for temporomandibular joint disorders patients: a systematic review and network meta-analysis of parallel randomized controlled trials

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Abstract

Purpose

To compare the effects of different energy density LLLT on TMD patients’ pain reduction.

Methods

Reviewers searched RCTs published in Embase, PubMed and The Cochrane Library before 1 April 2020. Reviewers included parallelRCTs that compared the effects of LLLT with placebo or different energy density LLLT for TMD patients’ pain reduction. Reviewers did network meta-analysis and evaluated the quality of evidence using the GRADE process.

Results

From 352 studies, reviewers included 16 RCTs. Immediately after treatment, the d1 laser therapy (energy density ranging from 0 to 10 J/cm2) ranked first. The d1 laser therapy showed more pain reduction than placebo ( MD = 2.49, 95% CI ranging from 1.28 to 3.71). The quality of “d1 vs p” comparison was assessed as “moderate” quality. A month after treatment, the d1 laser therapy also performed better than placebo (MD = 1.69, 95%CI = [-0.78, 4.16]). The quality of secondary outcome was assessed as “low” quality.

Conclusions

For clinical application, d1 laser therapy (energy density ranging from 0 to 10 J/cm2) is recommended for short-term pain management of TMD patients (moderate quality evidence). A month after treatment, the d1 laser therapy also performed better than placebo and other laser groups but the result didn’t reach the point of statistical significance (low quality evidence).

Trial registration: PROSPERO-CRD42018118313.

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Acknowledgments

This study was registered in PROSPERO. This work is funded by the National Natural Science Foundation of China (81660189).

Funding

This research received funding from National Natural Science Foundation of China (81660189).

Author information

Authors and Affiliations

  1. Department of Temporomandibular Joint and Occlusion, School/Hospital of Stomatology, Lanzhou University, Dong Gang Xi Road 199#, Lanzhou, 730000, People’s Republic of China

    Guoyi Jing, Fangrui Dong, Pengfei Zhang, Hui Ren, Jingying Liu, Yang Liu, Caiyun Yu, Jingjing Hu & Hong Kang

  2. Department of Orthodontics, Xiangya Hospital and School of Stomatology, Central South University, Changsha, 410078, People’s Republic of China

    Yatao Zhao

  3. Key Laboratory of Stomatology of State Ethnic Affairs Commission, Northwest Minzu University, Lanzhou, 730000, People’s Republic of China

    Guangjie Bao

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  1. Guoyi Jing
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Contributions

Jing G, Bao G and Kang H finished study design and relative studies search. Dong F, Zhang P and Jing G conducted study selection and the assessment of the risk of bias. Jing G and Kang H registered this SR in PROSPERO. Dong F, Zhang P, Ren H and Kang H finished data extraction. Jing G did the data analysis. All reviewers drafted and revised the manuscript. All reviewers agreed with final results and conclusions. Kang H took responsibility for the integrity of the work as a whole, from inception to finished article. The corresponding authors announced that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted.

Corresponding authors

Correspondence to Guangjie Bao or Hong Kang.

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The authors declared that there was no conflict of interests.

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This research received funding from National Natural Science Foundation of China (81660189).

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Jing, G., Zhao, Y., Dong, F. et al. Effects of different energy density low-level laser therapies for temporomandibular joint disorders patients: a systematic review and network meta-analysis of parallel randomized controlled trials. Lasers Med Sci 36, 1101–1108 (2021). https://doi.org/10.1007/s10103-020-03197-7

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  • DOI: https://doi.org/10.1007/s10103-020-03197-7

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