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Study of transcranial therapy 904 nm in experimental model of stroke

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Abstract

Cerebrovascular accidents (CVAs), commonly known as strokes, can damage the brain through vascular injuries caused by either blood vessel blockages (ischemic stroke) or ruptures (hemorrhagic stroke) which disrupt regular brain blood supply and can cause severe damage to the individual. The objective of the present study was to evaluate the effects of photobiomodulation with a light-emitting diode (LED) device (904 nm, 110 mW, 7 J/cm2) on neurogenesis, muscle resistance, and motor behavior in animals submitted to an experimental model of hemiplegia. The sample consisted of 30 Wistar rats, divided into two groups: control group (GC) and 904-nm LED-treated group (TG). All animals underwent stereotactic surgery for electrode implant and subsequent electrolytic injury to induce an ischemic stroke. TG was subjected to daily LED irradiation (904 nm, 110 mW, 7 J/cm2) for 63 s. Suspension test results indicate an improvement of TG muscle resistance when compared with baseline evaluation (BLT); a reduction in open-field freezing time and the number of fecal bolus pellets suggest diminished anxiety induced by 904-nm LED treatment on treatment days 7 and 21 (TG7 and TG21) compared with the baseline results; and lastly, histological analysis showed important signs of neurogenesis in TG in comparison to CG, especially on treatment days 7 and 21 (TG7 and TG21). In conclusion, the present study suggests that 904-nm LED irradiation may beneficially affect neurogenesis, muscle resistance, and animal motor behavior following ischemic CVA.

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Authors and Affiliations

  1. Programa de pós-Graduação em Ciências Farmaceuticas, Universidade Estadual do Centro-Oeste, Guarapuava, PR, Brazil

    Eliane Gonçalves de Jesus Fonseca

  2. Laboratory of Neuroanatomy and Neurophysiology, Universidade Estadual do Centro-Oeste, Guarapuava, PR, Brazil

    Ariele Pedroso & Débora Neuls

  3. Department of Physical Therapy, Functional Neurology Discipline, Universidade Estadual do Centro Oeste, Guarapuava, PR, Brazil

    Danilo Barbosa

  4. Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina, Palhoça, Santa Catarina, Brazil

    Francisco José Cidral-Filho

  5. Integrative Health School, Londrina, Paraná, Brazil

    Afonso Shiguemi Inoue Salgado

  6. Laboratório de Neuroanatomia e Neurofisiologia, Universidade Estadual do Centro-Oeste, Simeão Camargo Varela de Sá, 03, Guarapuava, Paraná, 88040-080, Brazil

    Angela Dubiela & Ivo Ilvan Kerppers

  7. Laboratório de Imunologia, virologia e Biologia Molecular, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil

    Emerson Carraro

Authors
  1. Eliane Gonçalves de Jesus Fonseca
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  2. Ariele Pedroso
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  3. Débora Neuls
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  4. Danilo Barbosa
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  5. Francisco José Cidral-Filho
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  6. Afonso Shiguemi Inoue Salgado
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  7. Angela Dubiela
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  8. Emerson Carraro
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  9. Ivo Ilvan Kerppers
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Corresponding author

Correspondence to Ivo Ilvan Kerppers.

Ethics declarations

All experiments were carried out in accordance with the Ethics Committee on the Use of Animals (CEUA) of the Central Western State University (UNICENTRO)—research protocol number 034/2017.

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The authors declare that there is no conflict of interest.

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de Jesus Fonseca, E.G., Pedroso, A., Neuls, D. et al. Study of transcranial therapy 904 nm in experimental model of stroke. Lasers Med Sci 34, 1619–1625 (2019). https://doi.org/10.1007/s10103-019-02758-9

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  • DOI: https://doi.org/10.1007/s10103-019-02758-9

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