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Light-emitting diode therapy (LEDT) improves functional capacity in rats with heart failure

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Abstract

The syndrome of heart failure (HF) promotes central and peripheral dysfunctions that result in functional capacity decrease, leading to fatigue, dyspnea, and exercise intolerance. The use of light-emitting diode therapy (LEDT) has shown good results reducing fatigue and exercise intolerance, when applied on skeletal muscles before or after exercises. Thereby, the aim of this study was to compare the effects of LEDT on functional capacity, aerobic power, and hemodynamic function in HF rats. Male Wistar rats (230–260 g) were randomly allocated into three experimental groups: Sham (n = 6), Control-HF (n = 4), and LEDT-HF (n = 6). The animals were subjected to an exercise performance test (ET) with gas analysis coupled in a metabolic chamber for rats performed two times (6 and 14 weeks after myocardial infarction). On the day after the baseline aerobic capacity test, the animals were submitted during 8 weeks to the phototherapy protocol, five times/week, 60 s of irradiation, 6 J delivered per muscle group. Statistical analysis was performed by one- and two-way ANOVAs with repeated measures and Student-Newman-Keuls post hoc tests (p ≤ 0.05). Comparing the percentage difference (Δ) between baseline and the final ET, there was no significant difference for the VO2max variable considering all groups. However, Sham and LEDT-HF groups showed higher relative values than the Control-HF group, respectively, for distance covered (27.7 and 32.5 %), time of exercise test (17.7 and 20.5 %), and speed (13.6 and 12.2 %). In conclusion, LEDT was able to increase the functional capacity evaluated by distance covered, time, and speed of exercise in rats with HF.

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Acknowledgments

We would like to acknowledge Edson Quagliotto (Ph.D.), Ramiro Barcos Nunes (Ph.D.), and Jadson Alves (M.Sc.) for their assistance during development of this study.

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Authors and Affiliations

  1. Laboratory of Experimental Physiology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil

    Lucas Capalonga, Marlus Karsten, Vítor Scotta Hentschke, Maurício Pinto Dornelles, Anelise Sonza & Pedro Dal Lago

  2. Post-Graduation Program in Rehabilitation Sciences, UFCSPA, Porto Alegre, Rio Grande do Sul, Brazil

    Lucas Capalonga, Marlus Karsten, Anelise Sonza & Pedro Dal Lago

  3. Post-Graduation Program in Health Sciences, UFCSPA, Porto Alegre, Rio Grande do Sul, Brazil

    Vítor Scotta Hentschke & Pedro Dal Lago

  4. Centro Universitário Franciscano, Santa Maria, Rio Grande do Sul, Brazil

    Douglas Dalcin Rossato

  5. Physics Institute of Sao Carlos, Universidade de São Paulo (USP), São Carlos, São Paulo, Brazil

    Vanderlei Salvador Bagnato & Cleber Ferraresi

  6. Laboratory of Electrothermophototherapy, Department of Physical Therapy, Universidade Federal de São Carlos (UFSCar), São Carlos, São Paulo, Brazil

    Cleber Ferraresi & Nivaldo Antonio Parizotto

  7. Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Harvard University, Boston, MA, USA

    Cleber Ferraresi

  8. Programa de Pós-Graduação em Ciências da Reabilitação (PPG-CR), Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, Porto Alegre, Rio Grande do Sul, 90050-170, Brazil

    Pedro Dal Lago

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  1. Lucas Capalonga
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  2. Marlus Karsten
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  3. Vítor Scotta Hentschke
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  10. Pedro Dal Lago
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Correspondence to Pedro Dal Lago.

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Funding

This research was supported by: Fundação de Amparo à Pesquisa do Rio Grande do Sul (FAPERGS, PRONEM—Programa de Núcleos Emergentes, 2011), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Chamada Universal, 2012), and Programa Nacional de Pós-doutorado da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, PNPD Concessão Institucional, 2011).

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.

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Capalonga, L., Karsten, M., Hentschke, V.S. et al. Light-emitting diode therapy (LEDT) improves functional capacity in rats with heart failure. Lasers Med Sci 31, 937–944 (2016). https://doi.org/10.1007/s10103-016-1922-y

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