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A novel approach for in-office tooth bleaching with 6 % H2O2/TiO_N and LED/laser system—a controlled, triple-blinded, randomized clinical trial

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Abstract

The purpose of this randomized, parallel, triple-blinded clinical trial was to compare efficacy and tooth sensitivity (TS) after use of an in-office bleaching agent of 6 % hydrogen peroxide containing nanoparticles of nitrogen-doped titanium oxide (HP6) vs. 35 % hydrogen peroxide (HP35). Forty-eight volunteers were randomly divided either a HP6 or HP35. Two clinical sessions were performed with an interval of 7 days between them for each group. In each session, two consecutive applications of each bleaching agent were performed and activated by a hybrid LED/laser light. Efficacy was determined by color alteration (ΔE), recorded with reflectance spectroscopy. It was assessed at baseline and after the first and second bleaching session. TS was characterized according to occurrence, intensity, duration, and type. Efficacy was analyzed by repeated measures analysis of variance (ANOVA) and post hoc Bonferroni test, and TS was analyzed by means of chi2 test (α = 0.05). For HP35, highest and significant values of ΔE were found after bleaching when compared to HP6 (p = 0.002). However, HP35 showed a significantly higher occurrence of TS than HP6 (p = 0.008). Also, intensity and duration were higher in HP35. The majority of volunteers classified the type experienced in their sensitivity in the form of a “shock.” The use of HP6 despite reducing efficacy when compared to an in-office bleaching in higher concentration (35 %) produced less tooth sensitivity. Clinical relevance: In terms of tooth sensitivity, the use of lower concentrations of in-office bleaching should be the first choice, suggesting greater biocompatibility and safety compared to a conventional HP35.

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Acknowledgments

This study was supported by CAPES.

We thank NUPEN and the undergraduate students Rafaela Nanami Handa Inada, Camila Yumi Morita, and Priscila Petrucelli Freire de Carvalho for the technical and scientific support.

We gratefully acknowledge the contribution of Michael Floros (Trent University, ON, Canada) for his English language and grammar corrections.

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Restorative Dentistry, School of Dentistry, UNESP - Universidade Estadual Paulista, 1680 Humaitá Street, Araraquara, SP, 14801-903, Brazil

    Janaina Freitas Bortolatto, Tamara Carolina Trevisan, Priscila Sadalla Ismael Bernardi, Livia Nordi Dovigo, Osmir Batista de Oliveira Junior & Hermes Pretel

  2. Department of Restorative Dentistry, School of Dentistry, School of Dentistry of Santiago, Universidad de Chile, Sergio Livingston 943, Independencia, Santiago, Chile

    Eduardo Fernandez

  3. Department of Restorative Dentistry, School of Dentistry, Faculdade de Odontologia, Universidade Estadual de Ponta Grossa, Rua Carlos Cavalcanti, 4748, São Paulo, CEP 84030-900, Brazil

    Alessandro Dourado Loguercio

Authors
  1. Janaina Freitas Bortolatto
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  2. Tamara Carolina Trevisan
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  3. Priscila Sadalla Ismael Bernardi
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  4. Eduardo Fernandez
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  5. Livia Nordi Dovigo
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  6. Alessandro Dourado Loguercio
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  7. Osmir Batista de Oliveira Junior
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  8. Hermes Pretel
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Corresponding author

Correspondence to Hermes Pretel.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare that they have no competing interests.

Additional information

Trial registration: U1111-1150-4466

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Bortolatto, J.F., Trevisan, T.C., Bernardi, P.S.I. et al. A novel approach for in-office tooth bleaching with 6 % H2O2/TiO_N and LED/laser system—a controlled, triple-blinded, randomized clinical trial. Lasers Med Sci 31, 437–444 (2016). https://doi.org/10.1007/s10103-016-1866-2

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  • DOI: https://doi.org/10.1007/s10103-016-1866-2

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