Abstract
Platelet-mediated thrombosis represents the initial precipitating event in the genesis of unstable angina, acute myocardial infarction, and stroke. As a result, there is considerable interest in the preclinical discovery and screening of new ‘anti-platelet’ therapies aimed at limiting the incidence and reoccurrence of arterial thrombosis—efforts that, to date, have largely required the use of large animal models of thrombotic occlusion. In the current report, we describe the successful development of a small-animal (rat) model of spontaneous and recurrent platelet-mediated arterial thrombosis achieved by the in vivo administration of a photoactive dye (rose bengal) followed by focal illumination with green laser light.
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Acknowledgement
This study was supported by a grant from the National Institutes of Health, Bethesda, MD (# R01 HL072684).
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Przyklenk, K., Whittaker, P. Adaptation of a photochemical method to initiate recurrent platelet-mediated thrombosis in small animals. Lasers Med Sci 22, 42–45 (2007). https://doi.org/10.1007/s10103-006-0410-1
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DOI: https://doi.org/10.1007/s10103-006-0410-1