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Connection between gut microbiome and the development of obesity

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Abstract

The potential role of the gut microbiota in various human diseases has attracted considerable attention worldwide. Here, we discuss the vital role of the intestinal microbiota in the development of obesity. First, we describe how the gut microbiota promotes fat accumulation. Additionally, a high-fat diet leads to structural instability among in the gut microbiota, further leading to an increase in endotoxins, which aggravates obesity. We then discuss how gut microbiota metabolites, including short-chain fatty acids and lipopolysaccharides, affect the host. Finally, we review several strategies for regulating the intestinal flora.

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Abbreviations

LPS:

lipopolysaccharides

TNF-α:

tumor necrosis factor-α

IL-1β:

interleukin 1β

LPL:

lipoprotein lipase

AMPK:

adenosine monophosphate–activated protein kinase

SCFAs:

short-chain fatty acids

FIAF:

fasting-induced adipocyte factor

Cpt1:

carnitine palmitoyl transferase-1

GPCRs:

G protein–coupled receptors

TLR:

Toll-like receptor

GLP:

glucagon-like peptide

CD:

clusters of differentiation

PGC-1α:

receptor-gamma coactivator-1α

UCP-1:

mitochondrial uncoupling protein-1

PYY:

peptide YY

HFD:

high-fat diet

TCA cycle:

tricarboxylic acid cycle

LCFAs:

long-chain fatty acids

Th.:

T helper

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Funding

This work was financially supported by the Industry University Research Collaborative Innovation Major Projects of Guangzhou Science Technology Innovation Commission, China (201604020164), Guangdong Provincial University Engineering Technology Research Center of Natural Products and Drugs (2017GCZX002), Technology Planning Project of Guangzhou, China (201806040009, 201804010349, 201804010329), and the National Science Foundation of China (no. 81173107).

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Authors and Affiliations

  1. Guangdong Engineering Research Center of Natural Products and New Drugs, Guangdong Provincial University Engineering Technology Research Center of Natural Products and Drugs, Guangdong Pharmaceutical University, Guangzhou, 510006, China

    Cuiting Zhi, Jingqing Huang, Jin Wang, Yan Bai & Zhengquan Su

  2. Guangdong Metabolic Diseases Research Centre of Integrated Chinese and Western Medicine, Guangdong TCM Key Laboratory for Metabolic Diseases, Key Laboratory of Modulating Liver to Treat Hyperlipemia SATCM, Level 3 Laboratory of Lipid Metabolism SATCM, Institute of Chinese Medicinal Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China

    Cuiting Zhi, Jingqing Huang, Jin Wang, Jiao Guo & Zhengquan Su

  3. School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan, 528458, China

    Hua Cao

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  1. Cuiting Zhi
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Cuiting Zhi had the idea for the article and drafted it. Jingqing Huang and Jin Wang performed the literature search. Cuiting Zhi, Yan Bai, Jiao Guo, and Zhengquan Su critically revised the work.

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Correspondence to Jiao Guo or Zhengquan Su.

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Zhi, C., Huang, J., Wang, J. et al. Connection between gut microbiome and the development of obesity. Eur J Clin Microbiol Infect Dis 38, 1987–1998 (2019). https://doi.org/10.1007/s10096-019-03623-x

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