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Impact of bacterial coinfection on clinical outcomes in pneumococcal pneumonia

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Abstract

The aim of this study was to investigate the influence of bacterial coinfection on patients with pneumococcal pneumonia. We retrospectively analyzed the incidence, clinical features, microbial distributions, and outcomes of patients with bacterial coinfection in a cohort of 433 hospitalized patients with pneumococcal pneumonia. Eighty-five patients (19.6 %) were diagnosed with bacterial coinfection; the most frequent pathogens were Haemophilus influenzae (25 patients, 33.3 %), methicillin-susceptible Staphylococcus aureus (MSSA) (15 patients, 20.0 %), and Moraxella catarrhalis (13 patients, 17.3 %). The CURB-65 score and pneumonia severity index (PSI) were significantly higher in patients with bacterial coinfection (both P < 0.001). In addition, the proportion of patients with bacterial coinfection who met the Infectious Disease Society of America (IDSA)/American Thoracic Society (ATS) severe pneumonia criteria was significantly higher (P < 0.001). Multivariate logistic regression analysis identified three risk factors for bacterial coinfection in patients with pneumococcal pneumonia: alcoholism (odds ratio [OR], 5.12; 95 % confidence interval (95 % CI), 1.60–16.4; P = 0.006), hospitalization for 2 days or more within 90 days preceding admission (OR, 2.02; 95 % CI, 1.03–3.98; P = 0.041), and residence in a nursing home or extended care facility (OR, 3.22; 95 % CI, 1.48–6.97; P = 0.003). Multivariate analysis for 30-day mortality showed that bacterial coinfection was a significant adverse prognostic factor (OR, 2.50; 95 % CI, 1.13–5.53; P = 0.023), independent of IDSA/ATS severe pneumonia, PSI, or healthcare-associated pneumonia. In conclusion, bacterial coinfection may have an adverse impact on severity and outcomes of pneumococcal pneumonia.

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Funding

This study was conducted without external financial support.

Conflict of interest

Tadashi Ishida has received honoraria from Taisyo-Toyama Pharmaceutical Co., Ltd., Pfizer Japan Inc., and MSD K.K. The other authors have no conflict of interest.

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Authors and Affiliations

  1. Department of Respiratory Medicine, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, 710-0052, Japan

    S. Kumagai, T. Ishida, H. Tachibana, Y. Ito, A. Ito & T. Hashimoto

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  1. S. Kumagai
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  2. T. Ishida
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  3. H. Tachibana
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  4. Y. Ito
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  5. A. Ito
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Correspondence to S. Kumagai.

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Kumagai, S., Ishida, T., Tachibana, H. et al. Impact of bacterial coinfection on clinical outcomes in pneumococcal pneumonia. Eur J Clin Microbiol Infect Dis 34, 1839–1847 (2015). https://doi.org/10.1007/s10096-015-2421-y

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  • DOI: https://doi.org/10.1007/s10096-015-2421-y

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