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The association between past Chlamydia pneumoniae infection and markers of chronic inflammation in obese women

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Abstract

It has been widely accepted that obesity is associated with chronic, low-grade inflammation that affects the adipose tissue as well as the entire system. The aim of this study was to assess whether past Chlamydia pneumoniae infection influences obesity phenotypes and serum levels of low-grade inflammation markers in obese, healthy premenopausal women. The study was performed on 48 obese and 42 normal-weight women, aged 31.2 ± 7.2 years. Serum levels of C-reactive protein (CRP), tumor necrosis factor α (TNFα) and its soluble receptor R2 (sTNF-R2), and interleukin 6 (IL-6) were measured. Body composition was assessed by bioimpendance. Insulin sensitivity was assessed by quantitative insulin sensitivity check index (QUICKI). The seroprevalence of C. pneumoniae infection was 69.1% and was similar in obese and normal-weight women (75.2% and 61.9%, respectively; P = 0.18). Obese women had higher CRP than healthy controls (P < 0.05). IL-6, TNFα, and sTNF-R2 showed no significant differences when comparing obese and normal-weight or C. pneumoniae infected and uninfected women. In multivariate regression analysis, fat mass (P < 0.001) and QUICKI (P < 0.01), accounting for 35% of the variance of CRP and C. pneumoniae infection, did not significantly contribute to this model (P = 0.51). In conclusion, past C. pneumoniae infection was not associated with changes in chronic inflammation markers in premenopausal obese women.

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Authors and Affiliations

  1. Department of Endocrinology, Metabolic Diseases and Internal Diseases, Pomeranian Medical University, ul. Arkońska 4, 71-455, Szczecin, Poland

    M. Koziołek, B. Krzyżanowska-Świniarska & T. Miazgowski

  2. Department of Microbiology and Immunology, Pomeranian Medical University, Szczecin, Poland

    I. Mączyńska & S. Giedrys-Kalemba

Authors
  1. M. Koziołek
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  2. B. Krzyżanowska-Świniarska
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  3. I. Mączyńska
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  4. T. Miazgowski
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  5. S. Giedrys-Kalemba
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Correspondence to T. Miazgowski.

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Koziołek, M., Krzyżanowska-Świniarska, B., Mączyńska, I. et al. The association between past Chlamydia pneumoniae infection and markers of chronic inflammation in obese women. Eur J Clin Microbiol Infect Dis 27, 415–421 (2008). https://doi.org/10.1007/s10096-007-0446-6

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  • DOI: https://doi.org/10.1007/s10096-007-0446-6

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