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Stroke in a young man with fibromuscular dysplasia of the cranial vessels with anticardiolipin antibodies: a case report

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Abstract

A case of fibromuscular dysplasia (FMD), presenting with a non-hemorrhagic infarct is reported. Positivity of anticardiolipin antibodies suggested an immune response. A 40-year-old man presented with sudden onset of stroke, preceded by similar ischemic attacks. Computed tomography (C1) of the brain showed a recent non-hemorrhagic infarct in the left middle cerebral artery (MCA) territory and an old right MCA territory infarct. Serum was positive for anticardiolipin antibodies. These above findings were confirmed at autopsy. A portion of the internal carotid artery and the middle cerebral arteries on both sides revealed features of FMD, with thrombosis. This case suggests an immune mechanism for FMD, hitherto unobserved in the cerebral circulation.

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Authors and Affiliations

  1. Department of Neurology, Room 703, C. N. Center, AIIMS, Ansari Nagar, New Delhi 110029, India, , , , , , IN

    M. Tripathi & P. S. Chandra

  2. Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India, , , , , , IN

    D. Nagaraj

  3. Department of Neuropathology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India, , , , , , IN

    V. Santosh & S. K. Shankar

  4. Department of Neurochemistry, National Institute of Mental Health and Neurosciences (NIMHANS), India, , , , , , IN

    R. Cristhopher

Authors
  1. M. Tripathi
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  2. V. Santosh
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  3. D. Nagaraj
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  4. R. Cristhopher
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  5. P. S. Chandra
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  6. S. K. Shankar
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Received: 27 November 2000 / Accepted in revised form: 3 April 2001

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Tripathi, M., Santosh, V., Nagaraj, D. et al. Stroke in a young man with fibromuscular dysplasia of the cranial vessels with anticardiolipin antibodies: a case report. Neurol Sci 22, 31–35 (2001). https://doi.org/10.1007/s100720170034

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  • DOI: https://doi.org/10.1007/s100720170034

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