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Metabolic syndrome and anthropometric indices in CTS hands: an electrophysiological study

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Abstract

Introduction

This study aims to evaluate the effect of metabolic syndrome (MetS) and anthropometric indices on carpal tunnel syndrome (CTS).

Methods

Forty-three healthy controls and 41 CTS patients were enrolled. Complaints of patients were assessed by Boston Questionnaire (BQ). MetS components were investigated. Wrist circumference, wrist depth, wrist width, palm width, and palm length were measured. Routine nerve conduction studies of median and ulnar nerves as well as the “sensitive” comparison tests were performed. Cutaneous silent period (CuSP) was studied by stimulating both second and fifth digital nerves while recording over thenar muscles.

Results

The vast majority of the participants were female and right-handed. CTS was bilateral in 61% of patients. Data of 109 hands were analyzed. MetS was more frequent in CTS patients. BQ scores were not related to MetS. Waist circumference, serum TG, and fasting glucose levels were higher in CTS patients. CTS hands with MetS had lower median CMAP amplitudes and increased sensory thresholds. Sensory thresholds were increased with both median and ulnar nerve stimulations suggesting a wider spread of peripheral nerve excitability changes in MetS presence. CuSPs were recorded from all 109 hands. CuSP latencies and durations were similar between controls and CTS patients. Wrist ratio was the only anthropometric index that was a statistically significant predictor for CTS development.

Conclusion

MetS was more prevalent in CTS patients. Some clinical and electrophysiological features (mainly sensory thresholds) may worsen in presence of MetS, but not the wrist ratio.

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Authors and Affiliations

  1. Department of Neurology, Bakirkoy Prof. Dr. Mazhar Osman Training and Research Hospital for Psychiatric, Neurologic, and Neurosurgical Diseases, University of Health Sciences, Zuhuratbaba mah, Dr. Tevfik Sağlam cad. No: 25/2, 34147, Bakırköy, Istanbul, Turkey

    Mahir Yusifov, Sezin Alpaydin Baslo, Betül Tekin, Mucahid Erdogan, Oya Ozturk & Dilek Atakli

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  1. Mahir Yusifov
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  2. Sezin Alpaydin Baslo
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  3. Betül Tekin
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Correspondence to Sezin Alpaydin Baslo.

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Ethical approval

Ethical approval was given by Ethical Committee of University of Health Sciences Bakirkoy Prof. Dr. Mazhar Osman Training and Research Hospital for Psychiatric, Neurologic and Neurosurgical Diseases with protocol number 25.09.2018–217.

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Informed consent was obtained from all individual participants included in the study.

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Both Mahir Yusifov and Sezin Alpaydin Baslo will be the first writers as co-authors.

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Yusifov, M., Alpaydin Baslo, S., Tekin, B. et al. Metabolic syndrome and anthropometric indices in CTS hands: an electrophysiological study. Neurol Sci 43, 1375–1384 (2022). https://doi.org/10.1007/s10072-021-05430-9

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  • DOI: https://doi.org/10.1007/s10072-021-05430-9

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