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Effectiveness of an herbaceous derivatives, PHGG, plus sodium hyaluronate in the treatment of chronic constipation in patients with Parkinson’s disease: a pilot study

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Abstract

Chronic constipation is a highly prevalent and often under-appreciated gastrointestinal disorder in PD associated with significant impairment in quality of life. In this study, we investigated the efficacy and safety of PHGG plus hyaluronate (PHGG+) in patients suffering from PD and constipation. Thirty-four PD patients have been recruited in an open-label pilot study and measured symptoms and quality of life instruments related to constipation. PHGG+ showed to have a minimal still significant effect in improving constipation as measured by PAC Symp and CGI-S. PHGG+ is safe and well tolerated. Data suggests that PHGG+ may be considered efficacious in alleviating symptoms of constipation in PD patients. Trial registration number: NCT04569656/24 Sept. 2020

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Authors and Affiliations

  1. Institute for Research and Medical Care, San Raffaele Roma Italy, Via della Pisana 235, 00163, Rome, Italy

    Laura Vacca, Stefania Proietti, Daniele Bravi & Fabiana Giada Radicati

  2. University and Institute for Research and Medical Care San Raffaele Roma Italy, Via della Pisana 235, 00163, Roma, Italy

    Fabrizio Stocchi

Authors
  1. Laura Vacca
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  2. Stefania Proietti
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  3. Daniele Bravi
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  4. Fabiana Giada Radicati
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  5. Fabrizio Stocchi
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Contributions

All the authors contributed to the ideation and conduction of the study. The manuscript has been revised by all the authors who contributed to it.

Corresponding author

Correspondence to Fabrizio Stocchi.

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The study was approved by IRCCS San Raffaele IRB.

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Vacca, L., Proietti, S., Bravi, D. et al. Effectiveness of an herbaceous derivatives, PHGG, plus sodium hyaluronate in the treatment of chronic constipation in patients with Parkinson’s disease: a pilot study. Neurol Sci 43, 1055–1059 (2022). https://doi.org/10.1007/s10072-021-05342-8

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  • DOI: https://doi.org/10.1007/s10072-021-05342-8

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