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Effects of functional electro-stimulation combined with blood flow restriction in affected muscles by spinal cord injury

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Abstract

Muscle atrophy is a great consequence of spinal cord injuries (SCI) due to immobility. SCI’s detrimental effects on large muscle groups may lead to secondary effects such as glucose intolerance, increased risk of metabolic syndrome, and diabetes. Exercising with blood flow restriction (BFR) has been proposed as an effective method to induce hypertrophy using low training loads, with little or no muscle damage. This study investigated acute and chronic effects of low-intensity functional electrical stimulation (FES) combined with BFR on muscles affected by spinal cord injury. The acute effects of one bout of FES with (FES + BFR group) and without BFR (FES group) on muscle thickness (MT) and edema formation were compared. The chronic effects on MT and edema following 8 weeks of twice weekly training with and without BFR were also compared. The FES + BFR group showed MT and edema increases compared to the FES only group (p< 0.05). The FES + BFR showed a chronic MT increase after 4 weeks of training (p <0.05), with no further MT increases from the 4th to the 8th week (p>0.05). Following 3 weeks of detraining, MT decreased to baseline. No MT changes were observed in the FES (p>0.05). The FES + BF stimuli induced MT increases on the paralyzed skeletal muscles of SCI. The acute effects suggest that FES causes a greater metabolite accumulation and edema when combined with BFR. The early increases in MT can be attributed to edema, whereas after the 4th week, it is likely to be related to muscle hypertrophy. Register Clinical Trial Number on ReBeC: RBR-386rm8

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  1. Motor Behavior Studies Center/Physiology Education Post Graduation Program, Federal University of Paraná, Curitiba, Brazil

    Gabriel H. Skiba, Sérgio F. Andrade & André F. Rodacki

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  1. Gabriel H. Skiba
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  3. André F. Rodacki
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All authors contributed to the design and implementation of the research and to the analysis of the results. Skiba wrote the paper, manufactured the figures, and acquired samples for research. Rodacki supervised the project.

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Correspondence to Gabriel H. Skiba.

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Skiba, G.H., Andrade, S.F. & Rodacki, A.F. Effects of functional electro-stimulation combined with blood flow restriction in affected muscles by spinal cord injury. Neurol Sci 43, 603–613 (2022). https://doi.org/10.1007/s10072-021-05307-x

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