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The alcoholic brain: neural bases of impaired reward-based decision-making in alcohol use disorders

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Abstract

Neuroeconomics is providing insights into the neural bases of decision-making in normal and pathological conditions. In the neuropsychiatric domain, this discipline investigates how abnormal functioning of neural systems associated with reward processing and cognitive control promotes different disorders, and whether such evidence may inform treatments. This endeavor is crucial when studying different types of addiction, which share a core promoting mechanism in the imbalance between impulsive subcortical neural signals associated with immediate pleasurable outcomes and inhibitory signals mediated by a prefrontal reflective system. The resulting impairment in behavioral control represents a hallmark of alcohol use disorders (AUDs), a chronic relapsing disorder characterized by excessive alcohol consumption despite devastating consequences. This review aims to summarize available magnetic resonance imaging (MRI) evidence on reward-related decision-making alterations in AUDs, and to envision possible future research directions. We review functional MRI (fMRI) studies using tasks involving monetary rewards, as well as MRI studies relating decision-making parameters to neurostructural gray- or white-matter metrics. The available data suggest that excessive alcohol exposure affects neural signaling within brain networks underlying adaptive behavioral learning via the implementation of prediction errors. Namely, weaker ventromedial prefrontal cortex activity and altered connectivity between ventral striatum and dorsolateral prefrontal cortex likely underpin a shift from goal-directed to habitual actions which, in turn, might underpin compulsive alcohol consumption and relapsing episodes despite adverse consequences. Overall, these data highlight abnormal fronto-striatal connectivity as a candidate neurobiological marker of impaired choice in AUDs. Further studies are needed, however, to unveil its implications in the multiple facets of decision-making.

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Authors and Affiliations

  1. Scuola Universitaria Superiore IUSS, 27100, Pavia, Italy

    Caterina Galandra, Stefano Cappa & Nicola Canessa

  2. IRCCS Istituti Clinici Scientifici Maugeri, 27100, Pavia, Italy

    Caterina Galandra & Gianpaolo Basso

  3. School of Medicine and Surgery, University of Milano-Bicocca, 20126, Milan, Italy

    Gianpaolo Basso

  4. IRCCS Centro San Giovanni di Dio – Fatebenefratelli, 25125, Brescia, Italy

    Stefano Cappa

  5. Cognitive Neuroscience Laboratory, IRCCS Istituti Clinici Scientifici Maugeri, 27100, Pavia, Italy

    Nicola Canessa

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Correspondence to Nicola Canessa.

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Galandra, C., Basso, G., Cappa, S. et al. The alcoholic brain: neural bases of impaired reward-based decision-making in alcohol use disorders. Neurol Sci 39, 423–435 (2018). https://doi.org/10.1007/s10072-017-3205-1

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