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New treatments for headache

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Abstract

Migraine and cluster headache are primary headache disorders commonly encountered in clinical practice. Despite the profound disability caused by these primary headache disorders, available acute and preventive treatment options are limited. Recent understanding of headache pathophysiology has led to the development of new drug formulations and novel drug targets that are extremely promising. This article will highlight several of the new treatments that are currently under investigation including novel delivery mechanisms of already existing medications, calcitonin gene-related peptide (CGRP) receptor antagonists, antibodies to CGRP and its receptor, serotonin receptor agonists, transient receptor potential vanilloid receptor modulators, orexin receptor antagonists, glial cell modulators, and neuromodulation. If data is supportive, these therapies will be welcome additions to the headache specialist’s armamentarium.

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Acknowledgments

Parts of this paper were adapted with permission from a previously published article written by the authors. Vollbracht and Rapoport [102].

Conflict of interest

S. Vollbracht has no actual or potential conflict of interest in relation to this article.

A. Rapoport serves on the speaker’s bureau of Allergan and Impax and serves on the advisory board of Depomed, Doctor Reddy’s, Impax, Merck, NuPathe Inc., and Winston Laboratories Inc. He is an editor of CNS Drugs, Headache, and Neurology Reviews.

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Authors and Affiliations

  1. Department of Neurology, Montefiore Headache Center, Albert Einstein College of Medicine, 1575 Blondell Avenue, Ste 225, Bronx, NY, 10461, USA

    Sarah Vollbracht

  2. The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Alan M. Rapoport

  3. The International Headache Society President, London, United Kingdom

    Alan M. Rapoport

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  1. Sarah Vollbracht
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Correspondence to Sarah Vollbracht.

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Vollbracht, S., Rapoport, A.M. New treatments for headache. Neurol Sci 35 (Suppl 1), 89–97 (2014). https://doi.org/10.1007/s10072-014-1747-z

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