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Lower serum uric acid levels in cerebral amyloid angiopathy: a pilot study

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Abstract

Cerebral amyloid angiopathy (CAA) is a common degenerative disease presenting intracerebral hemorrhage (ICH) in older people. Uric acid (UA) is a natural antioxidant, and may have a beneficial role in neurodegenerative diseases. Nevertheless, the role of UA in CAA remains unknown. In the present study, we compared serum UA levels in CAA-associated ICH patients (n = 82) and age/sex-matched controls (n = 82). Serum UA levels in possible CAA were significantly decreased when compared with healthy controls (232.68 ± 77.70 vs. 309.42 ± 59.83 μmol/L; p < 0.001). Furthermore, UA levels in patients clinically diagnosed as probable CAA were significantly lower than those in patients diagnosed as possible CAA (193.06 ± 56.98 vs. 232.68 ± 77.70 μmol/L; p = 0.014). These differences were still significant after adjusting for renal function and dyslipidemia (p < 0.001 and p = 0.002, respectively). However, there were no associations between serum UA levels and the distribution of hemorrhagic lesion, as well as neurological impairment. Our observations indicate that serum UA levels were decreased in CAA patients. UA might play a neuroprotective role in CAA and serve as a potential biomarker for reflecting the severity of Aβ deposition.

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Acknowledgments

This work was supported by a grant from National Natural Sciences Foundation of China (No. 81102689).

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The authors state that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Qi Hu, Mengyang Huang, Hong Jiang & Cuntai Zhang

  2. Experimental Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Anding Liu

  3. Department of Neurology, Jianli County General Hospital, Jianli, 433300, China

    Luo Cheng

  4. Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Huicong Kang, Feng Xu, Xiaoyan Liu, Lifei Lian, Qiming Liang & Suiqiang Zhu

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  1. Qi Hu
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  2. Anding Liu
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  3. Mengyang Huang
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  4. Luo Cheng
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  10. Hong Jiang
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  11. Cuntai Zhang
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Correspondence to Suiqiang Zhu.

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Hu, Q., Liu, A., Huang, M. et al. Lower serum uric acid levels in cerebral amyloid angiopathy: a pilot study. Neurol Sci 35, 1035–1039 (2014). https://doi.org/10.1007/s10072-014-1634-7

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  • DOI: https://doi.org/10.1007/s10072-014-1634-7

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