Abstract
The presence of episodic memory impairment is required for the diagnosis of Alzheimer’s dementia by all current diagnostic criteria. The new research criteria proposed by Dubois et al. (Lancet Neurol 6:734–746, 2007) require that the impairment should not improve significantly with cueing, recognition testing nor after the control of effective encoding. This is considered to be the core deficit of “prodromal Alzheimer’s disease”. The Free and Cued Selective Reminding Test (FCSRT) is a memory test that allows in assessing these specific features of memory impairment. Here, we report normative data for an Italian version of the FCSRT. The test is based on the 12 pictorial stimuli, 6 belonging to the living domain, and 6 to the non-living domain. Six scores were derived from the performance of 227 healthy Italian adults, with age, sex and education homogenously distributed across subgroups: immediate free recall (IFR), immediate total recall (ITR), delayed-free recall (DFR), delayed total recall (DTR), Index of Sensitivity of Cueing (ISC), number of intrusions. In multiple regression analyses, age emerged as an influencing factor for both IFR and DFR, with older people obtaining lower scores. Education and gender appear to influence only IFR, with better performance by more educated subjects and females. Adjusted scores were used to determine inferential cutoff scores and to compute equivalent scores.
Similar content being viewed by others
References
APA (2000) Diagnostic and statistical manual of mental disorders IV-TR. 4th edn — text revised, American Psychiatric Association, Washington
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 34:939–944
Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, Meguro K, O’Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P (2007) Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 6:734–746
Dubois B, Feldman HH, Jacova C, Cummings JL, Dekosky ST, Barberger-Gateau P, Delacourte A, Frisoni G, Fox NC, Galasko D, Gauthier S, Hampel H, Jicha GA, Meguro K, O’Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Sarazin M, de Souza LC, Stern Y, Visser PJ, Scheltens P (2010) Revising the definition of Alzheimer’s disease: a new lexicon. Lancet Neurol 9:1118–1127
Tulving E, Thomson DM (1973) Encoding specificity and retrieval processes in episodic memory. Psychol Rev 80:352–372
Ivnik RJ, Smith GE, Lucas JA, Tangalos EG, Kokmen E, Petersen RC (1997) Free and cued selective reminding test: MOANS norms. J Clin Exp Neuropsychol 19:676–691
Petersen RC, Smith GE, Ivnik RJ, Kokmen E, Tangalos EG (1994) Memory function in very early Alzheimer’s disease. Neurology 44:867–872
Petersen RC, Smith GE, Ivnik RJ, Tangalos EG, Schaid DJ, Thibodeau SN, Kokmen E, Waring SC, Kurland LT (1995) Apolipoprotein E status as a predictor of the development of Alzheimer’s disease in memory-impaired individuals. JAMA 273:1274–1278
Tuokko H, Vernon-Wilkinson R, Weir J, Beattie BL (1991) Cued recall and early identification of dementia. J Clin Exp Neuropsychol 13:871–879
Fossati P, Coyette F, Ergis AM, Allilaire JF (2002) Influence of age and executive functioning on verbal memory of inpatients with depression. J Affect Disord 68:261–271
Buschke H (1984) Cued recall in amnesia. J Clin Neuropsychol 6:433–440
Grober E, Buschke H (1987) Genuine memory deficits in dementia. Dev Neuropsychol 3:13–16
Grober E, Lipton RB, Hall C, Crystal H (2000) Memory impairment on free and cued selective reminding predicts dementia. Neurology 54:827–832
Pasquier F, Grymonprez L, Lebert F, Van der Linden M (2001) Memory impairment differs in frontotemporal dementia and Alzheimer’s disease. Neurocase 7:161–171
Pillon B, Deweer B, Michon A, Malapani C, Agid Y, Dubois B (1994) Are explicit memory disorders of progressive supranuclear palsy related to damage to striatofrontal circuits? Comparison with Alzheimer’s, Parkinson’s, and Huntington’s diseases. Neurology 44:1264–1270
Sarazin M, Berr C, De Rotrou J, Fabrigoule C, Pasquier F, Legrain S, Michel B, Puel M, Volteau M, Touchon J, Verny M, Dubois B (2007) Amnestic syndrome of the medial temporal type identifies prodromal AD: a longitudinal study. Neurology 69:1859–1867
Sarazin M, Chauvire V, Gerardin E, Colliot O, Kinkingnehun S, de Souza LC, Hugonot-Diener L, Garnero L, Lehericy S, Chupin M, Dubois B (2010) The amnestic syndrome of hippocampal type in Alzheimer’s disease: an MRI study. J Alzheimers Dis 22:285–294
Carlesimo GA, Perri R, Caltagirone C (2011) Category cued recall following controlled encoding as a neuropsychological tool in the diagnosis of Alzheimer’s disease: a review of the evidence. Neuropsychol Rev 21:54–65
Grober E, Buschke H, Crystal H, Bang S, Dresner R (1988) Screening for dementia by memory testing. Neurology 38:900–903
Saka E, Mihci E, Topcuoglu MA, Balkan S (2006) Enhanced cued recall has a high utility as a screening test in the diagnosis of Alzheimer’s disease and mild cognitive impairment in Turkish people. Arch Clin Neuropsychol 21:745–751
O’Connell ME, Tuokko H (2002) The 12-item Buschke memory test: appropriate for use across levels of impairment. Appl Neuropsychol 9:226–233
Grober E, Lipton RB, Katz M, Sliwinski M (1998) Demographic influences on free and cued selective reminding performance in older persons. J Clin Exp Neuropsychol 20:221–226
Pena-Casanova J, Gramunt-Fombuena N, Quinones-Ubeda S, Sanchez-Benavides G, Aguilar M, Badenes D, Molinuevo JL, Robles A, Barquero MS, Payno M, Antunez C, Martinez-Parra C, Frank-Garcia A, Fernandez M, Alfonso V, Sol JM, Blesa R (2009) Spanish Multicenter Normative Studies (NEURONORMA Project): norms for the Rey-Osterrieth complex figure (copy and memory), and free and cued selective reminding test. Arch Clin Neuropsychol 24:371–393
Snodgrass JG, Vanderwart M (1980) A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J Exp Psychol Hum Learn 6:174–215
Auriacombe S, Helmer C, Amieva H, Berr C, Dubois B, Dartigues JF (2010) Validity of the free and cued selective reminding test in predicting dementia: the 3C study. Neurology 74:1760–1767
Lekeu F, Van der Linden M, Chicherio C, Collette F, Degueldre C, Franck G, Moonen G, Salmon E (2003) Brain correlates of performance in a free/cued recall task with semantic encoding in Alzheimer disease. Alzheimer Dis Assoc Disord 17:35–45
Tounsi H, Deweer B, Ergis AM, Van der Linden M, Pillon B, Michon A, Dubois B (1999) Sensitivity to semantic cuing: an index of episodic memory dysfunction in early Alzheimer disease. Alzheimer Dis Assoc Disord 13:38–46
Grober E, Merling A, Heimlich T, Lipton RB (1997) Free and cued selective reminding and selective reminding in the elderly. J Clin Exp Neuropsychol 19:643–654
Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198
Viggiano MP, Vannucci M, Righi S (2004) A new standardized set of ecological pictures for experimental and clinical research on visual object processing. Cortex 40:491–509
Dell’Acqua R, Lotto L, Job R (2000) Naming times and standardized norms for the Italian PD/DPSS set of 266 pictures: direct comparisons with American, English, French, and Spanish published databases. Behav Res Methods Instrum Comput 32:588–615
Capitani E, Laiacona M (1997) Composite neuropsychological batteries and demographic correction: standardization based on equivalent scores, with a review of published data. The Italian Group for the Neuropsychological Study of Ageing. J Clin Exp Neuropsychol 19:795–809
Wilks SS (1941) Determination of sample sizes for setting tolerance limits. Ann Math Stat 12:91–96
Silveri MC, Daniele A, Giustolisi L, Gainotti G (1991) Dissociation between knowledge of living and nonliving things in dementia of the Alzheimer type. Neurology 41:545–546
Tippett LJ, Grossman M, Farah MJ (1996) The semantic memory impairment of Alzheimer’s disease: category-specific? Cortex 32:143–153
Author information
Authors and Affiliations
Corresponding author
Additional information
An erratum to this article can be found at http://dx.doi.org/10.1007/s10072-012-0973-5.
Appendix
Appendix
See Table 5.
Rights and permissions
About this article
Cite this article
Frasson, P., Ghiretti, R., Catricalà, E. et al. Free and cued selective reminding test: an Italian normative study. Neurol Sci 32, 1057–1062 (2011). https://doi.org/10.1007/s10072-011-0607-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10072-011-0607-3