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BRD2 and TAP-1 genes and juvenile myoclonic epilepsy

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Abstract

Juvenile myoclonic epilepsy (JME) is a genetically determined common subtype of idiopathic generalized epilepsy. Linkage of JME to the chromosomal region 6p21.3 has been reported. An association has been previously observed between JME and the positional candidate, 6p21.3 linked, BRD2. Another candidate in this region is the TAP-1 gene encoding the Transporter Associated with Antigen Processing. The aim of the present study is to determine whether these two genes modulate the vulnerability to JME. While no difference was observed in the allele and genotype frequencies of BRD2 between JME and controls, an association was found between a TAP-1 haplotype and JME, suggesting that this gene may be another 6p21.3 linked vulnerability factor to JME.

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Acknowledgments

This study was supported by the University Hospital of Geneva and the Swiss Telethon Foundation (to A.M.).

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Authors and Affiliations

  1. Laboratoire de Physiologie, Faculté de Médecine de Monastir, Monastir, Tunisia

    Samia Layouni & Mohamed Dogui

  2. Service de Médecine Génétique, Hôpitaux Universitaires de Genève, Geneva, Switzerland

    Catherine Buresi & Alain Malafosse

  3. Service de Neurologie, CHU, Nice, France

    Pierre Thomas

  4. Département de Psychiatrie, Université de Genève, Geneva, Switzerland

    Alain Malafosse

  5. Service d’Explorations Fonctionnelles du Système Nerveux, Hôpital Universitaire Sahloul de Sousse, Sousse, Tunisia

    Mohamed Dogui

  6. Service de Médecine Génétique, Hôpital Belle Idée, 2 chemin du Petit Bel Air, 1225, Chêne Bourg, Switzerland

    Alain Malafosse

Authors
  1. Samia Layouni
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  2. Catherine Buresi
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  3. Pierre Thomas
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  4. Alain Malafosse
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  5. Mohamed Dogui
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Corresponding author

Correspondence to Alain Malafosse.

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Layouni, S., Buresi, C., Thomas, P. et al. BRD2 and TAP-1 genes and juvenile myoclonic epilepsy. Neurol Sci 31, 53–56 (2010). https://doi.org/10.1007/s10072-009-0190-z

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  • DOI: https://doi.org/10.1007/s10072-009-0190-z

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