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Dietary supplementation with Ceriporia lacerata improves learning and memory in a scopolamine-induced amnesia mouse model

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Abstract

Ceriporia lacerata (CL) is a species of white rot fungi. In this study, we have examined the beneficial effect of CL on scopolamine-induced memory impairment in mice. A freeze-dried CL mycelial culture broth was dissolved and orally administered to scopolamine-treated C57BL/6J mice followed by behavioral tests using the Y-maze, passive avoidance, and Morris water maze tasks. CL administration at a daily dose of 200 mg/kg body weight resulted in restoration of exploration reduction and improvement of associative and spatial learning and memory impairment in scopolamine-treated mice. Concomitantly, heme oxygenase-1 was highly expressed in the hippocampal region of CL-administered mice. Moreover, the ethanolic extract of CL significantly increased the transcriptional activity of antioxidant response element and attenuated the glutamate-induced cytotoxicity in HT22 mouse hippocampal neuronal cells. These findings suggest that the CL intake can confer a beneficial effect on learning and memory presumably through protecting hippocampal neuronal cells from oxidative stress-induced damage.

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Acknowledgements

This research was funded by the “Food Functionality Evaluation program” under the Ministry of Agriculture, Food, and Rural Affairs and partly by the Korea Food Research Institute (2019), Republic of Korea.

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Supplementary Figure S1

. (A) Animal experimental scheme. (B) Body weight changes of mice during the whole experimental period. Supplementary Figure S2. The relative abundance of microbiota analyzed from rectal and excreted fecal samples acquired from powdered CL-administered mice. (A–B) The proportion of three major microbial phyla in rectal feces (A) and excreted feces (B) obtained from control mice. (C–D) The relative abundance of the three phyla in rectal feces (C) and excreted feces (D) from CL-administered mice at a dose of 200, 500 or 800 mg/kg BW/day, as opposed to control mice. Statistically significant differences are indicated by an asterisk in comparison to the control group within a set of phyla (p < 0.05).. Supplementary file 1 (PDF 467 kb)

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Lee, S., Lim, J.S., Yun, H.S. et al. Dietary supplementation with Ceriporia lacerata improves learning and memory in a scopolamine-induced amnesia mouse model. Food Sci Biotechnol 30, 1107–1116 (2021). https://doi.org/10.1007/s10068-021-00945-5

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