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Physiological and molecular study on the anti-obesity effects of pineapple (Ananas comosus) juice in male Wistar rat

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Abstract

The present study was performed to assess anti-obesity effects of raw pineapple juice in high fat diet (HFD)-induced fatness. Based on food type, rats were divided into normal diet and HFD groups. When animals of HFD group become obese, they were given pineapple juice along with either HFD or normal diet. Blood biochemistry, liver and muscle gene expressions were analyzed. HFD induced significant elevations in body weight, body mass index (BMI), body fat accumulation, liver fat deposition and blood lipids while juice restored these parameters near to their normal values. Juice significantly decreased serum insulin and leptin while adiponectin was increased. Juice administration downregulated the increment of FAS and SERBP-1c mRNA expression in liver and upregulated HSL and GLUT-2 expressions. The muscular lipolytic CPT-1 expression was upregulted by juice treatment. Pineapple juice, therefore, may possibly be used as anti-obesity candidate where it decreased lipogenesis and increased lipolysis.

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Acknowledgements

We are thankful to Taif University in Kingdom of Saudi Arabia for supporting this work financially (Project No. 1-437-4742).

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Authors and Affiliations

  1. Department of Biotechnology, College of Science, Taif University, Taif, Saudi Arabia

    Samir A. El-Shazly & Mohamed E. Alkafafy

  2. Department of Biochemistry, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt

    Samir A. El-Shazly

  3. Department of Biochemistry, Faculty of Veterinary Medicine, University of Sadat City, Sādāt City, Egypt

    Mohamed M. Ahmed

  4. Department of Biology, College of Science, Taif University, Taif, Saudi Arabia

    Mohammad S. AL-Harbi

  5. Department of Cytology and Histology, Faculty of Veterinary Medicine, University of Sadat City, Sādāt City, Egypt

    Mohamed E. Alkafafy

  6. Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Kaferelsheikh University, Kaferelsheikh, Egypt

    Hanan B. El-Sawy

  7. Department of Forensic Biology, College of Forensic Sciences, Naif Arab University for Security Sciences, P.O. 6830, Riyadh, Saudi Arabia

    Sayed A. M. Amer

  8. Zoology Department, Faculty of Science, Cairo University, Giza, Egypt

    Sayed A. M. Amer

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  1. Samir A. El-Shazly
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  2. Mohamed M. Ahmed
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  3. Mohammad S. AL-Harbi
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  4. Mohamed E. Alkafafy
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Correspondence to Sayed A. M. Amer.

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El-Shazly, S.A., Ahmed, M.M., AL-Harbi, M.S. et al. Physiological and molecular study on the anti-obesity effects of pineapple (Ananas comosus) juice in male Wistar rat. Food Sci Biotechnol 27, 1429–1438 (2018). https://doi.org/10.1007/s10068-018-0378-1

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  • DOI: https://doi.org/10.1007/s10068-018-0378-1

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