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Whitening effects of 4-hydroxyphenethyl alcohol isolated from water boiled with Hizikia fusiformis

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Abstract

Isolation of phenolic compounds from water boiled with Hizikia fusiformis and purificartrion of the extracts from solvent fractions was achieved using column chromatography. The simple phenolic compound, 4-hydroxyphenethyl alcohol (4-HPEA) with an elemental composition C8H10O2 was identified on the basis of spectroscopic data. The whitening effects of 4-HPEA, inhibitory activity against mushroom tyrosinase, and inhibitory activity against melanin production in B16 melanoma cells were evaluated using an in vitro assay system. The whitening effect of 4-HPEA was also measured using a colorimeter and visual assessment of UVB induced hyperpigmentation of brown guinea pig skin. Topical application of 4-HPEA promoted depigmentation of UVB-induced hyperpigmented spots. 4-HPEA has a potential for use as a safe and effective ingredient for whitening in cosmetic and medical applications.

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  1. Food and Safety Research Division, National Fisheries Research and Development Institute (NFRDI), Busan, 619-705, Korea

    Mi-Soon Jang, Hee-Yeon Park & Ki-Ho Nam

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  1. Mi-Soon Jang
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Jang, MS., Park, HY. & Nam, KH. Whitening effects of 4-hydroxyphenethyl alcohol isolated from water boiled with Hizikia fusiformis . Food Sci Biotechnol 23, 555–560 (2014). https://doi.org/10.1007/s10068-014-0076-6

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  • DOI: https://doi.org/10.1007/s10068-014-0076-6

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