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Inhibitory activity of aromadendrin from prickly pear (Opuntia ficus-indica) root on aldose reductase and the formation of advanced glycation end products

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Abstract

Prickly pear (Opuntia ficus-indica) is a longdomesticated crop plant of arid and semiarid parts of the world. The efficacy of extracts of prickly pear root for managing diabetes and diabetes complications was evaluated using a variety of in vitro bioassays. The ethyl acetate-soluble fraction was most effective in the prevention of diabetes and its complications via the inhibition of rat lens aldose reductase activity, the formation of advanced glycation end products, and α-glucosidase activity. MS and NMR were used to identify the bioactive compound from the ethyl acetate-soluble fraction as 3,5,7,4′-tetrahydroxyflavanone (aromadendrin).

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References

  1. DeFronzo RA. Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes. Diabetes Rev. 5: 177–269 (1997)

    Google Scholar 

  2. Callahan ST, Mansfield MJ. Type 2 diabetes mellitus in adolescents. Curr. Opin. Pediatr. 12: 310–315 (2000)

    Article  CAS  Google Scholar 

  3. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care 27: 1047–1053 (2004)

    Article  Google Scholar 

  4. Kawanishi K, Ueda H, Moriyasu M. Aldose reductase inhibitors from the nature. Curr. Med. Chem. 10: 1353–1374 (2003)

    Article  CAS  Google Scholar 

  5. Chung SS, Chung SK. Aldose reductase in diabetic microvascular complications. Curr. Drug. Targets 6: 475–486 (2005)

    Article  CAS  Google Scholar 

  6. Cui CB, Jeong SK, Lee YS, Lee SO, Kang IJ, Lim SS. Inhibitory activity of caffeoylquinic acids from the aerial parts of Artemisia princeps on rat lens aldose reductase and on the formation of advanced glycation end products. J. Korean Soc. Appl. Biol. Chem. 52: 655–662 (2009)

    Article  CAS  Google Scholar 

  7. Ahmed N. Advanced glycation endproducts-role in pathology of diabetic complications Diabetes Res. Clin. Pr. 67: 3–21 (2005)

    CAS  Google Scholar 

  8. Peyroux J, Sternberg M. Advanced glycation endproducts (AGEs): Pharmacological inhibition in diabetes. Pathol. Biol. 54: 405–419 (2006)

    Article  CAS  Google Scholar 

  9. Gillies CL, Abrams KR, Lambert PC, Cooper NJ, Sutton AJ, Hsu RT, Khunti K. Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: Systematic review and meta-analysis. Brit. Med. J. 334: 299–302 (2007)

    Article  Google Scholar 

  10. Butterweck V, Semlin L, Feistel B, Pischel I, Bauer K, Verspohl EJ. Comparative evaluation of two different Opuntia ficus-indica extracts for blood sugar lowering effects in rats. Phytother. Res. 25: 370–375 (2010)

    Google Scholar 

  11. Feugang JM, Konarski P, Zou D, Stintzing FC, Zou C. Nutritional and medicinal use of cactus pear (Opuntia spp.) cladodes and fruits. Front. Biosci. 11: 2574–2589 (2006)

    Article  CAS  Google Scholar 

  12. Ibanez-Camacho R, Meckes-Lozoya M. Effect of a semipurified product obtained from Opuntia streptacantha L. (a cactus) on glycemia and triglyceridemia of rabbit. Arch. Invest. Med. 14: 437–443 (1983)

    CAS  Google Scholar 

  13. Ibanez-Camacho R, Meckes-Lozoya M, Mellado-Campos V. The hypoglucemic effect of Opuntia streptacantha studied in different animal experimental models. J. Ethnopharmacol. 7: 175–181 (1983)

    Article  CAS  Google Scholar 

  14. Lee EH, Kim HJ, Song YS, Jin C, Lee KT, Cho J, Lee YS. Constituents of the stems and fruits of Opuntia ficus-indica var. saboten. Arch. Pharm. Res. 26: 1018–1023 (2003)

    Article  CAS  Google Scholar 

  15. Lopez D. Review: Use of the fruits and stems of the prickly pear cactus (Opuntia spp.) into human food. Food Sci. Tech. Int. 1: 65–74 (1995)

    Article  Google Scholar 

  16. Andrade-Cetto A, Heinrich M. Mexican plants with hypoglycaemic effect used in the treatment of diabetes. J. Ethnopharmacol. 99: 325–348 (2005)

    Article  Google Scholar 

  17. Banos G, Perez-Torres I, El Hafidi M. Medicinal agents in the metabolic syndrome. Cardiovasc. Hematol. Agents Med. Chem. 6: 237–252 (2008)

    Article  CAS  Google Scholar 

  18. Frati-Munari AC, de Leon C, Ariza-Andraca R, Banales-Ham MB, Lopez-Ledesma R, Lozoya X. Effect of a dehydrated extract of nopal (Opuntia ficus indica Mill.) on blood glucose. Arch. Invest. Med. 20: 211–216 (1989)

    CAS  Google Scholar 

  19. Frati-Munari AC, Fernandez-Harp JA, Banales-Ham M, Ariza-Andraca CR. Decreased blood glucose and insulin by nopal (Opuntia sp.). Arch. Invest. Med. 14: 269–274 (1983)

    CAS  Google Scholar 

  20. Trejo-Gonzalez A, Gabriel-Ortiz G, Puebla-Perez AM, Huizar-Contreras MD, Munguia-Mazariegos MR, Mejia-Arreguin S, Calva E. A purified extract from prickly pear cactus (Opuntia fuliginosa) controls experimentally induced diabetes in rats. J. Ethnopharmacol. 55: 27–33 (1996)

    Article  CAS  Google Scholar 

  21. Shim JH, Park JT, Hong JS, Kim KW, Kim MJ, Auh JH, Kim YW, Park CS, Boos W, Kim JW, Park KH. Role of maltogenic amylase and pullulanase in maltodextrin and glycogen metabolism of Bacillus subtilis 168. J. Bacteriol. 191: 4835–4844 (2009)

    Article  CAS  Google Scholar 

  22. Lee YS, Kang YH, Jung JY, Kang IJ, Han SN, Chung JS, Shin HK, Lim SS. Inhibitory constituents of aldose reductase in the fruiting body of Phellinus linteus. Biol. Pharm. Bull. 31: 765–768 (2008)

    Article  CAS  Google Scholar 

  23. Prasad S, Sinha AK. Free radical activity in hypertensive type 2 diabetic patients. Int. J. Dib. Mel. 2: 141–143 (2010)

    Google Scholar 

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Authors and Affiliations

  1. Department of Food Science and Nutrition & Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon, Gangwon, 200-702, Korea

    Young Eun Jeon, Xing Fu Yin, Dan Bi Choi, Soon Sung Lim, Il-Jun Kang & Jae-Hoon Shim

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  1. Young Eun Jeon
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  2. Xing Fu Yin
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  3. Dan Bi Choi
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  4. Soon Sung Lim
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  6. Jae-Hoon Shim
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Correspondence to Jae-Hoon Shim.

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Jeon, Y.E., Yin, X.F., Choi, D.B. et al. Inhibitory activity of aromadendrin from prickly pear (Opuntia ficus-indica) root on aldose reductase and the formation of advanced glycation end products. Food Sci Biotechnol 20, 1283–1288 (2011). https://doi.org/10.1007/s10068-011-0177-4

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  • DOI: https://doi.org/10.1007/s10068-011-0177-4

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