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Comparison of Crataegus pinnatifida Bunge var. typica Schneider and C. pinnatifida Bunge fruits for antioxidant, anti-α-glucosidase, and anti-inflammatory activities

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Abstract

Two different species of hawthorn, Crataegus pinnatifida Bunge var. typica Schneider (CBS) and Crataegus pinnatifida Bunge (CB) are traditional medicinal plants, which belong to the Crataegus genus of the Rosaceae family. In this study, the antioxidant, anti-α-glucosidase, and anti-inflammatory activities of CBS and CB methanolic extracts were measured. The CB extract showed significantly higher antioxidant activity than CBS extract by several antioxidants properties. Anti-diabetes activity was expressed as α-glucosidase inhibits activity, both extracts showed very low anti-diabetes activity. Furthermore, the inhibitory activity on lipopolysaccharide (LPS) induced nitric oxide (NO) production and pro-inflammatory iNOS and COX-2 mRNA levels were measured. The CBS extract exhibited stronger anti-inflammatory activity than CB extract. Compared the present findings of 2 kinds of Crataegus species, the CB is more suitable for further anti-oxidative research. However, the CBS can potentially be developed into products for the prevention of inflammatory related diseases.

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Authors and Affiliations

  1. Division of Medical Biotechnology, Kangwon National University, Chuncheon, Gangwon, 200-701, Korea

    Chunmei Li & Myeong-Hyeon Wang

  2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, PR China

    Chaoqing Huang

  3. Department of Otolaryngology, College of Medicine, Kangwon National University, Chuncheon, Gangwon, 200-701, Korea

    Seok Ki Lee

  4. College of Animal Life Sciences, Kangwon National University, Chuncheon, Gangwon, 200-701, Korea

    Jayant Lohakare

  5. Department of Anesthesiology, Kangwon National University Hospital, School of Medicine, Kangwon National University Chuncheon, Gangwon, 200-701, Korea

    Hee Jeong Son

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  1. Chunmei Li
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  2. Hee Jeong Son
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  3. Chaoqing Huang
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Correspondence to Myeong-Hyeon Wang.

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Li, C., Son, H.J., Huang, C. et al. Comparison of Crataegus pinnatifida Bunge var. typica Schneider and C. pinnatifida Bunge fruits for antioxidant, anti-α-glucosidase, and anti-inflammatory activities. Food Sci Biotechnol 19, 769–775 (2010). https://doi.org/10.1007/s10068-010-0108-9

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  • DOI: https://doi.org/10.1007/s10068-010-0108-9

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