Abstract:
The cell distribution and function of alveolar macrophages and T lymphocytes were investigated in the bronchoalveolar lavage (BAL) of 15 patients with systemic sclerosis (SSc). In alveolar macrophages, both spontaneous and PMA-stimulated TNF-α production were increased in SSc. PMA-induced IL-6 production was also elevated. Spontaneous IL-6 excretion of scleroderma alveolar macrophages was similar to the controls. Yeast and C3b-coated yeast (opsonised yeast) phagocytosis, chemotaxis and Fc receptor activity of alveolar macrophages were normal. The proportion of CD3, CD4 and CD8 T-lymphocyte subsets in the BAL was similar to the control values. The lymphocyte blast transformation index of the non-adherent cells deriving from the BAL fluid was markedly decreased.
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Received: 12 March 1998 / Accepted: 10 December 1998
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Czirják, L., Koncz, A., Varga, I. et al. Investigation of the Alveolar Macrophages and T Lymphocytes in 15 Patients with Systemic Sclerosis. Clin Rheumatol 18, 357–363 (1999). https://doi.org/10.1007/s100670050119
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DOI: https://doi.org/10.1007/s100670050119