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Myocarditis of Mixed Connective Tissue Disease: Favourable Outcome after Intravenous Pulsed Cyclophosphamide

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Abstract:

A 30-year-old woman with mixed connective tissue disease was admitted with Wernicke’s aphasia and progressive dyspnoea with chest pain. Multiple brain infarcts on a computed tomographic scan were compatible with a thromboembolic aetiology. Echocardiography showed marked hypokinesia of the posterior wall, biventricular dilatation and a decreased left-ventricle ejection fraction (40%). A diagnosis of myocarditis was made on myocardial biopsies disclosing interstitial lymphocytic infiltrates and myocardial fibre necrosis. A treatment with steroids and monthly pulsed cyclophosphamide was introduced. The heart function rapidly improved as assessed by a left-ventricle ejection fraction of 55% and remained stable 17 months thereafter.

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Authors and Affiliations

  1. Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, , , , , , CH

    C. Hammann & F. Spertini

  2. Department of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, , , , , , CH

    C. Y. Genton

  3. Division of Cardiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, , , , , , CH

    A. Delabays

  4. Division of Nuclear Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, , , , , , CH

    A. Bischoff Delaloye

  5. Service of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, , , , , , CH

    J. Bogousslavsky

Authors
  1. C. Hammann
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  2. C. Y. Genton
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  3. A. Delabays
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  4. A. Bischoff Delaloye
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  5. J. Bogousslavsky
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  6. F. Spertini
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Received: 10 November 1997 / Accepted: 22 June 1998

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Hammann, C., Genton, C., Delabays, A. et al. Myocarditis of Mixed Connective Tissue Disease: Favourable Outcome after Intravenous Pulsed Cyclophosphamide. Clin Rheumatol 18, 85–87 (1999). https://doi.org/10.1007/s100670050062

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  • DOI: https://doi.org/10.1007/s100670050062

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