Skip to main content

Advertisement

SpringerLink
Log in

Serum levels of fetuin-A as a novel biomarker for disease activity in patients with Takayasu arteritis and granulomatous polyangiitis

  • Original Article
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

Objective

The aim of the present study was to investigate serum fetuin-A (Fet-A) levels in patients with Takayasu arteritis (TA) and granulomatous polyangiitis (GPA) and to analyze the relationship between serum Fet-A levels and disease activity scores.

Method

Thirty-two TA and 28 GPA patients presented to the rheumatology clinic at Gazi University and met the criteria of American College of Rheumatology 1990 and 2012 International Chapell Hill meeting, respectively, and 20 healthy control subjects were included in the present study. We collected data on serum C-reactive protein (CRP), albumin, calcium, and phosphate levels as well as erythrocyte sedimentation rates. Calcification risk index (CRI) was calculated for each patient. The Birmingham Vasculitis Activity Score (BVAS) and Indian Takayasu Clinical Activity Score (ITAS), were used to assess disease activity in GPA and TA patients respectively.

Results

Serum Fet-A levels were significantly lower in the overall vasculitis group compared to control group (p = 0.015). In subgroup analysis, Fet-A levels were significantly lower in those with active disease, compared to control group (p = 0.001, for active TA (n = 18) and GPA (n = 17), respectively). However, there was no significant difference in serum Fet-A levels in inactive cases versus control subjects (p = 0.061, for inactive TA (n = 14) and GPA (n = 11), respectively). Serum Fet-A levels negatively correlated with BVAS (r =  − 0.675) and ITAS scores (r =  − 0.385), as well as with CRP and CRI.

Conclusion

Our results suggest that serum Fet-A level could be a novel biomarker for assessment of activity status in patients with GPA or TA.

Key Points

• Serum Fetuin-A is negative acute phase protein and systemic calcification inhibitor synthesized in hepatocytes and secreted by various inflammation.

• Serum Fetuin-A was negatively correlated with CRP, BVAS, and ITAS scores and significantly decreased in vasculitis patients with high disease activity.

• Serum Fetuin-A could be a promising and useful biomarker for the assessment of disease activity for vasculitis, also that it might also be a predictor of long-term cardiovascular progression.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. L Bourebaba K Marycz 2019 Pathophysiological implication of Fetuin-A glycoprotein in the development of metabolic disorders: a concise review J Clin Med 8 12 2033

    Article  CAS  Google Scholar 

  2. MA Icer H Yıldıran 2021 Effects of fetuin-A with diverse functions and multiple mechanisms on human health Clin Biochem 88 1 10 https://doi.org/10.1016/j.clinbiochem.2020.11.004

    Article  PubMed  CAS  Google Scholar 

  3. I Jialal R Pahwa 2019 Fetuin-A is also an adipokine Lipids Health Dis 18 1 73 https://doi.org/10.1186/s12944-019-1021-8

    Article  PubMed  PubMed Central  Google Scholar 

  4. K Mori M Emoto M Inaba 2011 Fetuin-A: a multifunctional protein Recent Pat Endocr Metab Immune Drug Discov 5 2 124 146 https://doi.org/10.2174/187221411799015372

    Article  PubMed  CAS  Google Scholar 

  5. Angela Yee-Moon Wang 2005 Jean Woo, Christopher Wai-Kei Lam, Mei Wang, Iris Hiu-Shuen Chan, Ping Gao, Siu-Fai Lui, Philip Kam-Tao Li, John E Sanderson, Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients, Nephrology Dialysis Transplantation 20 8 1676 1685 https://doi.org/10.1093/ndt/gfh891

    Article  CAS  Google Scholar 

  6. Icer Mehmet Arif, and Hilal Yıldıran. “Effects of nutritional status on serum fetuin-A level.” Critical reviews in food science and nutrition 60.11 (2020): 1938–1946.

  7. Atta DS, Emera A, Ghoneim RS, Elnaggar AM. Serum level of fetuin-A in systemic lupus erythematosus patients: association with atherosclerosis and disease activity. Clin Rheumatol. 2021 Jan 7. doi: https://doi.org/10.1007/s10067-020-05521-6. Epub ahead of print. PMID: 33415453.

  8. Jäger E. Calcium, Phosphat und der Calcium-Sensing-Rezeptor: Ein proinflammatorischer Mix bei rheumatoider Arthritis [Calcium, phosphate and the calcium-sensing receptor: a proinflammatory combination in rheumatoid arthritis]. Z Rheumatol. 2021 Feb;80(1):65–68. German. doi: https://doi.org/10.1007/s00393-020-00937-6.

  9. Paul A Monach 2014 Biomarkers in vasculitis Curr Opin Rheumatol 26 1 24

    Article  CAS  Google Scholar 

  10. GS Kerr CW Hallahan J Giordano RY Leavitt AS Fauci M Rottem GS Hoffman 1994 Takayasu arteritis Ann Intern Med 120 11 919 929

    Article  CAS  Google Scholar 

  11. E Lupi-Herrera G Sanchez-Torres J Marcushamer J Mispireta S Horwitz JE Vela 1977 Takayasus arteritis. Clinical study of 107 cases Am Heart J 93 1 94 103

    Article  CAS  Google Scholar 

  12. C Mukhtyar R Lee D Brown D Carruthers B Dasgupta S Dubey O Flossmann C Hall J Hollywood D Jayne R Jones P Lanyon A Muir D Scott L Young RA Luqmani 2009 Modification and validation of the Birmingham Vasculitis Activity Score (version 3) Ann Rheum Dis 68 12 1827 1832 https://doi.org/10.1136/ard.2008.101279

    Article  CAS  Google Scholar 

  13. Misra R, Danda D, Rajappa SM, Ghosh A, Gupta R, Mahendranath KM, Jeyaseelan L, Lawrence A, Bacon PA; Indian Rheumatology Vasculitis (IRAVAS) group. Development and initial validation of the Indian Takayasu Clinical Activity Score (ITAS2010). Rheumatology (Oxford). 2013 Oct;52(10):1795–801. doi: https://doi.org/10.1093/rheumatology/ket128. Epub 2013 Apr 16. PMID: 23594468.

  14. RHJA Slart Writing group., Slart, R.H.J.A. 2018 FDG-PET/CT(A) imaging in large vessel vasculitis and polymyalgia rheumatica: joint procedural recommendation of the EANM, SNMMI, and the PET Interest Group (PIG), and endorsed by the ASNC Eur J Nucl Med Mol Imaging 45 1250 1269 https://doi.org/10.1007/s00259-018-3973-8

    Article  PubMed  PubMed Central  Google Scholar 

  15. Ishihara, Takashi, et al. “Diagnosis and assessment of Takayasu arteritis by multiple biomarkers.” Circulation Journal (2012): CJ-12.

  16. P Bacon R Sivakumar D Danda R Misra 2012 Vasculitis assessment and Takayasu aorto-arteritis Indian Journal of rheumatology 7 3 153 158

    Article  Google Scholar 

  17. AF Abdel-Wahab O Fathy R Al-Harizy 2013 Negative correlation between fetuin-A and indices of vascular disease in systemic lupus erythematosus patients with and without lupus nephritis Arab J Nephrol Transplant 6 1 11 20 PMID: 23282228

    PubMed  Google Scholar 

  18. J Kamińska M Stopiński K Mucha A Jędrzejczak M Gołębiowski MA Niewczas L Pączek B Foroncewicz 2019 IL 6 but not TNF is linked to coronary artery calcification in patients with chronic kidney disease Cytokine 120 9 14 https://doi.org/10.1016/j.cyto.2019.04.002

    Article  PubMed  CAS  Google Scholar 

  19. E Nogueira S Hamour D Sawant S Henderson N Mansfield K-M Chavele CD Pusey AD Salama 2010 Serum IL-17 and IL-23 levels and autoantigen-specific Th17 cells are elevated in patients with ANCA-associated vasculitis Nephrol Dial Transplant 25 7 2209 2217 https://doi.org/10.1093/ndt/gfp783

    Article  PubMed  CAS  Google Scholar 

  20. Y Sun X Kong X Cui 2020 The value of interleukin-6 in predicting disease relapse for Takayasu arteritis during 2-year follow-up Clin Rheumatol 39 3417 3425 https://doi.org/10.1007/s10067-020-05066-8

    Article  PubMed  Google Scholar 

  21. Dabrowska, Anna Maria, et al. “Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature.” Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 159.3 (2015): 352-359

  22. Herrmann M, Babler A, Moshkova I, et al. Lumenal calcification and microvasculopathy in fetuin-A-deficient mice lead to multiple organ morbidity. PLoS One. 2020;15(2):e0228503. Published 2020 Feb 19. doi: https://doi.org/10.1371/journal.pone.0228503

  23. Clemente, Alberto, et al. “Vascular and valvular calcification biomarkers.” Advances in clinical chemistry 95 (2020): 73–103.

  24. S Banerjee M Bagheri V Sandfort MA Ahlman AA Malayeri DA Bluemke J Yao PC Grayson 2019 Vascular calcification in patients with large-vessel vasculitis compared to patients with hyperlipidemia Semin Arthritis Rheum 48 6 1068 1073 https://doi.org/10.1016/j.semarthrit.2018.09.001

    Article  PubMed  CAS  Google Scholar 

  25. GH Heine M Nangaku D Fliser 2013 Calcium and phosphate impact cardiovascular risk Eur Heart J 34 15 1112 1121 https://doi.org/10.1093/eurheartj/ehs353

    Article  PubMed  CAS  Google Scholar 

  26. C King L Harper 2017 Avoidance of harm from treatment for ANCA-associated vasculitis Current treatment options in rheumatology 3 4 230 243

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Division of Rheumatology, Facultyof Medicine, Gazi University, 06100, Ankara, Turkey

    Hazan Karadeniz, Aslıhan Avanoğlu Güler, Reyhan Bilici Salman, Hasan Satış, Nuh Ataş, Hakan Babaoğlu, Hamit Küçük, Abdurrahman Tufan, Mehmet Akif Öztürk, Berna Göker & Şeminur Haznedaroğlu

  2. Department of Biochemistry, FacultyofMedicine, Gazi University, Ankara, Turkey

    Gülce Koca & Hatice Paşaoğlu

Authors
  1. Hazan Karadeniz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Aslıhan Avanoğlu Güler
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gülce Koca
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Reyhan Bilici Salman
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hasan Satış
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Nuh Ataş
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hakan Babaoğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hatice Paşaoğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hamit Küçük
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Abdurrahman Tufan
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Mehmet Akif Öztürk
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Berna Göker
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Şeminur Haznedaroğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hazan Karadeniz.

Ethics declarations

Ethical approval

This study was approved by Gazi University ethics committee, conducted in accordance with the 1975 Helsinki Declaration.

Disclosures

None.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Karadeniz, H., Güler, A.A., Koca, G. et al. Serum levels of fetuin-A as a novel biomarker for disease activity in patients with Takayasu arteritis and granulomatous polyangiitis. Clin Rheumatol 41, 1169–1176 (2022). https://doi.org/10.1007/s10067-021-06020-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-021-06020-y

Keywords

Search

Navigation