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Different ethnic background is associated with distinct clinical profiles in the spondyloarthritides in the North and South of Brazil

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Abstract

The objective of this study was to analyze the clinical profile of the spondyloarthritides (SpA) in distinct Brazilian regions. A common protocol of investigation was prospectively applied to 202 SpA patients, including 138 patients from the South and 64 patients from the North. All the patients were classified as axial or peripheral SpA. Clinical and demographic variables and disease indexes were analyzed. Bonferroni correction was used to adjust the level of significance of each test; results with p value < 0.003 were considered statistically relevant. White ethnicity was associated with positive HLA-B27, while non-Whites presented higher frequency of peripheral arthritis, although not statistically significant. When comparing non-White patients from the North with those from the South, the Southerners presented significantly higher scores of Ankylosing Spondylitis Disease Activity Score using C-reactive protein (p = 0.001) and Health Assessment Questionnaire (p = 0.001). Although not statistically significant, Northern non-White patients were more frequently males, while Southerners had higher frequency of anterior uveitis and higher Bath Ankylosing Spondylitis Disease Activity Index and Ankylosing Spondylitis Quality of Life. Brazilian SpA patients present distinct patterns of disease according to the geographic region, especially regarding the non-White populations.

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Authors and Affiliations

  1. Department of Internal Medicine, Faculdade de Medicina, Universidade Federal do Amazonas, Manaus, Brazil

    Sandra Lúcia Euzébio Ribeiro, Marta Aline Coelho da Costa & Talita de Oliveira Ribeiro

  2. Department of Rheumatology, Hospital Universitário Evangélico, Curitiba, Brazil

    Ana Paula Beckhauser de Campos

  3. Department of Rheumatology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

    Penélope Esther Palominos

  4. Insper Institute of Education and Research, São Paulo, Brazil

    Adriana Bruscato Bortoluzzo

  5. Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil

    Percival Degrava Sampaio-Barros

  6. Disciplina de Reumatologia da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455 3° andar, sala 3131, Cerqueira César, São Paulo, 01246-903, Brazil

    Percival Degrava Sampaio-Barros

Authors
  1. Sandra Lúcia Euzébio Ribeiro
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  2. Ana Paula Beckhauser de Campos
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  3. Penélope Esther Palominos
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  4. Adriana Bruscato Bortoluzzo
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  5. Marta Aline Coelho da Costa
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  6. Talita de Oliveira Ribeiro
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  7. Percival Degrava Sampaio-Barros
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Corresponding author

Correspondence to Percival Degrava Sampaio-Barros.

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This research has been approved by the local Ethics in Research Committees of the three centers and all enrolled patients signed an informed consent.

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Ribeiro, S.L.E., de Campos, A.P.B., Palominos, P.E. et al. Different ethnic background is associated with distinct clinical profiles in the spondyloarthritides in the North and South of Brazil. Clin Rheumatol 38, 195–203 (2019). https://doi.org/10.1007/s10067-018-3997-2

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  • DOI: https://doi.org/10.1007/s10067-018-3997-2

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