Abstract
We investigated the rate of rheumatoid factor (RF) false positivity at diagnosis and its influence on clinical and prognostic features and rheumatoid arthritis (RA) development during the follow-up in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients without RA or other medical conditions triggering RF false positivity. We reviewed the medical records of 128 AAV patients. We divided patients with AAV and each variant into two groups according to RF positivity and compared variables between the two groups. Odds ratio and cumulative relapse-free survival rate were obtained by multivariate logistic regression analysis and the Kaplan-Meier survival analysis, respectively. The mean age at diagnosis was 53.6 years and 41 patients were male. Of 128 AAV patients, 69 patients (53.9%) were classified as microscopic polyangiitis (MPA), 29 (22.7%) as granulomatosis with polyangiitis (GPA) and 30 (23.4%) as eosinophilic GPA (EGPA). The rate of RF false positivity was 39.1% in AAV patients. On univariate analysis, general, cutaneous and mucous and ocular manifestations and myeloperoxidase (MPO)-ANCA (or perinuclear (P)-ANCA) positivity were associated with RF false positivity in patients with AAV. On multivariate analysis, cutaneous manifestation was the only independent predictor of RF false positivity in EGPA patients. RF false positivity had no influence on cumulative relapse-free survival rate of AAV or RA development during the follow-up. RF false positivity rate was 39.1% in AAV patients and it was associated with cutaneous manifestation in EGPA patients at diagnosis, but not relapses of AAV or RA development during the follow-up.
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Sun J, Zhang Y, Liu L, Liu G (2014) Diagnostic accuracy of combined tests of anti cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis: a meta-analysis. Clin Exp Rheumatol 32(1):11–21
Carson DA, Chen PP, Kipps TJ, Roudier J, Silverman GJ, Tighe H (1989) Regulation of rheumatoid factor synthesis. Clin Exp Rheumatol 7(Suppl 3):S69–S73
Teitsson I (1988) IgA rheumatoid factor as predictor of disease activity. Scand J Rheumatol Suppl 75:233–237
Mariette X (2001) Lymphomas complicating Sjögren’s syndrome and hepatitis C virus infection may share a common pathogenesis: chronic stimulation of rheumatoid factor B cells. Ann Rheum Dis 60(11):1007–1010
Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F et al (2013) 2012 revised international Chapel Hill consensus conference nomenclature of vasculitides. Arthritis Rheum 65(1):1–11
Kallenberg CG (2014) The diagnosis and classification of microscopic polyangiitis. J Autoimmun 48-49:90–93
Greco A, De Virgilio A, Rizzo MI, Gallo A, Magliulo G, Fusconi M et al (2015) Microscopic polyangiitis: advances in diagnostic and therapeutic approaches. Autoimmun Rev 14(9):837–844
Falk RJ, Gross WL, Guillevin L, Hoffman G, Jayne DR, Jennette JC et al (2011) Granulomatosis with polyangiitis (Wegener’s): an alternative name for Wegener’s granulomatosis. Ann Rheum Dis 70(4):704
Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Ruoppolo G et al (2015) Churg-Strauss syndrome. Autoimmun Rev 14(4):341–348
Watts R, Lane S, Hanslik T, Hauser T, Hellmich B, Koldingsnes W et al (2007) Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies. Ann Rheum Dis 66(2):222–227
Leavitt RY, Fauci AS, Bloch DA, Michel BA, Hunder GG, Arend WP et al (1990) The American College of Rheumatology 1990 criteria for the classification of Wegener’s granulomatosis. Arthritis Rheum 33(8):1101–1107
Masi AT, Hunder GG, Lie JT, Michel BA, Bloch DA, Arend WP et al (1990) The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum 33(8):1094–1100
Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd et al (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 69(9):1580–1588
Mukhtyar C, Lee R, Brown D, Carruthers D, Dasgupta B, Dubey S et al (2009) Modification and validation of the Birmingham Vasculitis Activity Score (version 3). Ann Rheum Dis 68(12):1827–1832
Stone JH, Hoffman GS, Merkel PA, Min YI, Uhlfelder ML, Hellmann DB et al (2001) A disease-specific activity index for Wegener’s granulomatosis: modification of the Birmingham Vasculitis Activity Score. International Network for the Study of the Systemic Vasculitides (INSSYS). Arthritis Rheum 44(4):912–920
Shim CN, Hwang JW, Lee J, Koh EM, Cha HS, Ahn JK (2012) Prevalence of rheumatoid factor and parameters associated with rheumatoid factor positivity in Korean health screening subjects and subjects with hepatitis B surface antigen. Mod Rheumatol 22(6):885–891
Choi ST, Lee HW, Song JS, Lee SK, Park YB (2014) Analysis of rheumatoid factor according to various hepatitis B virus infectious statuses. Clin Exp Rheumatol 32(2):168–173
Skare TL, Silva MB, Holler AP, Chavez PA (2009) Protective role of rheumatoid factor in lupus nephritis. Clin Exp Rheumatol 27(5):895
Reininger L, Berney T, Shibata T, Spertini F, Merino R, Izui S (1990) Cryoglobulinemia induced by a murine IgG3 rheumatoid factor: skin vasculitis and glomerulonephritis arise from distinct pathogenic mechanisms. Proc Natl Acad Sci U S A 87(24):10038–10042
Ullman S, Høier-Madsen M, Halberg P, Jans H, Sylvest J (1979) Deposits of immunoglobulins and complement in skin of patients with rheumatoid arthritis. Influence of anti-rheumatic treatment. Scand J Rheumatol 8(2):119–123
Julian BA, Czerkinsky C, Russell MW, Galla JH, Koopman WJ, Mestecky J et al (1987) Striking elevation of serum IgA, IgA-containing immune complexes, and IgA rheumatoid factor in clinically silent dermatitis herpetiformis. Am J Kidney Dis 10(5):378–384
Kudou M, Yasuba H, Kobayashi Y, Hamada K, Kita H (2006) Correlation between rheumatoid factor and peripheral eosinophil count in chronic eosinophilic pneumonia. Respirology 11(6):830–832
Boudou L, Alexandre C, Thomas T, Pallot-Prade B (2010) Chronic eosinophilic pneumonia (Carrington’s disease) and rheumatoid arthritis. Joint Bone Spine 77(5):477–480
Howard TW, Iannini MJ, Burge JJ, Davis JS 4th (1991) Rheumatoid factor, cryoglobulinemia, anti-DNA, and renal disease in patients with systemic lupus erythematosus. J Rheumatol 18(6):826–830
Tarkowski A, Westberg G (1987) Rheumatoid factor isotypes and renal disease in systemic lupus erythematosus. Scand J Rheumatol 16(5):309–312
Gordon C, Jayne D, Pusey C, Adu D, Amoura Z, Aringer M et al (2009) European consensus statement on the terminology used in the management of lupus glomerulonephritis. Lupus 18(3):257–263
Jennette JC, Falk RJ, Hu P, Xiao H (2013) Pathogenesis of antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis. Annu Rev Pathol 8:139–160
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This study was approved by the institutional Review Board of Severance Hospital (4-2016-0901).
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Moon, JS., Lee, D.DH., Park, YB. et al. Rheumatoid factor false positivity in patients with ANCA-associated vasculitis not having medical conditions producing rheumatoid factor. Clin Rheumatol 37, 2771–2779 (2018). https://doi.org/10.1007/s10067-017-3902-4
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DOI: https://doi.org/10.1007/s10067-017-3902-4