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Association of MCP-1-2518A/G polymorphism with susceptibility to autoimmune diseases: a meta-analysis

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Abstract

We performed a meta-analysis to estimate whether combined evidence shows the association between the MCP-1-2518A/G polymorphism and susceptibility to autoimmune diseases. Relevant articles dated to July 2014 were acquired from the PubMed, EMBASE, ISI, and CNKI databases. The number of the genotypes and/or alleles for the MCP-1-2518A/G in cases and control subjects was extracted, and statistical analysis was conducted using STATA 11.2 software. Summary odds ratios (ORs) with their 95 % confidence intervals (95 % CIs) were used to calculate the risk of autoimmune diseases with the MCP-1-2518A/G. Significant increased risk of autoimmune diseases could be found for A allele vs. G allele (OR = 1.616, 95 % CI 1.027–2.542, P = 0.038) and AA + AG vs. GG (OR = 1.616, 95 % CI 1.027–2.542, P = 0.038) in Asian patients with rheumatoid arthritis (RA), and for A allele vs. G allele (OR = 1.383, 95 % CI 1.142–1.676, P = 0.022) and AA vs. AG + GG (OR = 1.575, 95 % CI 1.361–1.823, P < 0.001) in European patients with Crohn’s disease (CD). In addition, when comparison of European patients with lupus nephritis (LN) and without LN, significant association between patients with LN and without LN also could be found for AA vs. AG + GG (OR = 0.713, 95 % CI 0.545–0.933, P = 0.014). This meta-analysis showed that the MCP-1-2518-A allele confers susceptibility to Asian patients with RA and European patients with CD.

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Acknowledgments

We thank all our colleagues working in the Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology.

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    Authors and Affiliations

    1. Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, 41 Damucang Hutong, Xicheng District, 100032, Beijing, China

      Si Chen, Chuiwen Deng, Chaojun Hu, Jing Li, Xiaoting Wen, Ziyan Wu, Yuan Li, Fengchun Zhang & Yongzhe Li

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    1. Si Chen
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    Correspondence to Yongzhe Li.

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    Si Chen and Chuiwen Deng contributed equally to this work.

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    Fig. S1

    Forest plots of all models for SSc in overall meta-analysis. (GIF 172 kb)

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    Fig. S2

    Forest plots of all models for SLE in overall meta-analysis. (GIF 298 kb)

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    Fig. S3

    Forest plots of all models for SLE in stratified meta-analysis (GIF 285 kb)

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    Fig. S4

    Forest plots of all models for IgAN in overall meta-analysis. (GIF 254 kb)

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    Fig. S5

    Forest plots of all models for RA in overall meta-analysis. (GIF 192 kb)

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    Fig. S6

    Forest plots of other models for CD in overall meta-analysis and forest plots of other models for RA in stratified meta-analysis. (GIF 209 kb)

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    Fig. S7

    Forest plots of other models for SLE with LN patients vs. controls in overall meta-analysis (GIF 133 kb)

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    Fig. S8

    Forest plots of all models for SLE with LN patients vs. controls in stratified meta-analysis. (GIF 228 kb)

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    Fig. S9

    Forest plots of all models for SLE without LN patients vs. controls in overall meta-analysis. (GIF 270 kb)

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    Fig. S10

    Forest plots of all models for SLE without LN patients vs. controls in stratified meta-analysis. (GIF 279 kb)

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    Fig. S11

    Forest plots of all models for SLE with LN patients vs. SLE without LN patients in overall meta-analysis. (GIF 254 kb)

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    Fig. S12

    Forest plots of other models for SLE with LN patients vs. SLE without LN patients in stratified meta-analysis. (GIF 210 kb)

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    Fig. S13

    The results of sensitivity analysis from SLE without LN patients vs. controls. (GIF 188 kb)

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    Fig. S14

    The results of sensitivity analysis from SLE with LN patients vs. controls. (GIF 205 kb)

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    Fig. S15

    The results of sensitivity analysis from SLE with LN patients vs. SLE without LN patients. (GIF 204 kb)

    High resolution image (TIFF 2700 kb)

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    Chen, S., Deng, C., Hu, C. et al. Association of MCP-1-2518A/G polymorphism with susceptibility to autoimmune diseases: a meta-analysis. Clin Rheumatol 35, 1169–1179 (2016). https://doi.org/10.1007/s10067-015-3060-5

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