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Evaluation of current therapeutic strategies in Behçet’s disease

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Abstract

Behçet’s disease (BD) is a chronic relapsing vasculitis with multifunctional pathogenesis. The mucocutaneous and ocular lesions are the commonest manifestations, but BD also affects the musculoskeletal, intestinal, cardiac, and central nervous system. BD therapy is based on the suppression of the inflammatory process, using immunomodulating and immunosuppressive agents. In selected cases, invasive procedures may be required.

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Abbreviations

BD:

Behcet disease

IL:

Interleukin

TNFα:

Tumor Necrosis Factor

PTX:

Pentoxifylline

CsA:

Cyclosporin A

AZA:

Azathioprine

IFNα:

Interferon α

ANA:

Antinuclear antibodies

MMP:

Matrix metalloprotease

CNS:

Central nervous system

CSF:

Cerebrospinal fluid

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Author information

Authors and Affiliations

  1. First Department of Internal Medicine, University of Athens, Laikon Hospital, 69 Vosporou Str, Athens, 10444, Greece

    Iliana Alexoudi, Aristides Vaiopoulos, Meletios Kanakis & George Vaiopoulos

  2. Department of Microbiology, Medical School, University of Athens, Athens, Greece

    Violetta Kapsimali

Authors
  1. Iliana Alexoudi
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  2. Violetta Kapsimali
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  3. Aristides Vaiopoulos
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  4. Meletios Kanakis
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  5. George Vaiopoulos
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Correspondence to Iliana Alexoudi.

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Alexoudi, I., Kapsimali, V., Vaiopoulos, A. et al. Evaluation of current therapeutic strategies in Behçet’s disease. Clin Rheumatol 30, 157–163 (2011). https://doi.org/10.1007/s10067-010-1566-4

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  • DOI: https://doi.org/10.1007/s10067-010-1566-4

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