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An unusual association: anti-Jo1 and anti-SRP antibodies in the serum of a patient with polymyositis

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Abstract

The idiopathic inflammatory myopathies are systemic autoimmune diseases characterized by chronic inflammation, resulting in the progressive weakness of the proximal muscles. Myositis-specific or myositis-associated autoantibodies can often be found in serum of polymyositis and dermatomyositis patients. This autoantibody presence may play a significant role in patient diagnosis and classification. We present a female polymyositis patient characterized with serious muscle weakness and lung involvement. Anti-Jo1 antibodies were detected in the patient’s serum at the time of diagnosis. After 5 years of treatment and surveillance, recent laboratory analysis showed the presence anti-SRP antibody in her serum.

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Abbreviations

IIM:

Idiopathic inflammatory myopathies

PM:

Polymyositis

MSA:

Myositis-specific autoantibodies

MAA:

Myositis-associated autoantibodies

CK:

Serum creatine kinase

LDH:

Serum lactate dehydrogenase

SGOT:

Serum aspartate aminotransferase

SGPT:

Serum alanine aminotransferase

Anti-Jo-1:

Anti-histidyl-tRNA antibody

Anti-SRP:

Antibody against signal recognition particle

EMG:

Electromyography

ENG:

Electroneurography

HRCT:

High resolution computer tomography

ILD:

Intersticial lung disease

Qol:

Quality of life

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Written informed consent was obtained from the patient for publication of this case report.

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Authors and Affiliations

  1. Division of Immunology, 3rd Department of Internal Medicine, Institute for Internal Medicine, University of Debrecen Medical and Health Science Center, Moricz Zs. krt. 22, 4032, Debrecen, Hungary

    Melinda Vincze, Peter A. Molnár & Katalin Dankó

  2. Regional Immunology Laboratory, 3rd Department of Internal Medicine, Institute for Internal Medicine, University of Debrecen Medical and Health Science Center, Moricz Zs. krt. 22, 4032, Debrecen, Hungary

    Judit Tumpek, Lászlóné Szőllősi, Ágnes Gyetvai & Anikó Kapitány

Authors
  1. Melinda Vincze
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  2. Peter A. Molnár
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  3. Judit Tumpek
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  4. Lászlóné Szőllősi
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  5. Ágnes Gyetvai
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  6. Anikó Kapitány
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  7. Katalin Dankó
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Corresponding author

Correspondence to Katalin Dankó.

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Vincze, M., Molnár, P.A., Tumpek, J. et al. An unusual association: anti-Jo1 and anti-SRP antibodies in the serum of a patient with polymyositis. Clin Rheumatol 29, 811–814 (2010). https://doi.org/10.1007/s10067-010-1394-6

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  • DOI: https://doi.org/10.1007/s10067-010-1394-6

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