Abstract
Differences in the aetiology of osteoarthritis (OA) of the first carpometacarpal joints (CMC-1) and the interphalangeal joints (IP) have been reported. It was the purpose of this investigation to evaluate whether isolated OA of the first carpometacarpal joints and the interphalangeal joints differs in its aetiology, considering potential risk factors such as age, gender, body mass index, occupational history, OA in the hip or knee joints, hypertension and diabetes in patients with advanced hip or knee OA. Included in this investigation were 639 patients scheduled for either hip or knee replacement because of advanced OA. As well as a standardised interview and clinical examination, bilateral radiographs of both hands were obtained. According to the presence or absence of radiographic OA, participants were categorised as having CMC-1 OA (= 1 joint) or IP OA (= 2 joints), either isolated or in combination. Odds ratios (OR) and their 95% confidence intervals (CI) for potential determinants of OA were estimated using multivariable logistic regression.Of the total number of patients, 184 had CMC-1 OA and 424 IP OA. Patients with CMC-1 OA were more likely to be female (77.2%), and to have knee OA (62.5%) and hypertension (63.0%), than patients without CMC-1 OA. No differences between CMC-1 OA and IP OA were observed for the role of age, body mass index and diabetes. Age was associated with both CMC and IP OA. Female gender was independently associated with CMC-1 OA (OR=1.79; 95% CI: 1.16–2.74) but not with IP OA. Our data suggest a possible impact of age and female gender on the aetiology of CMC-1 OA and of age on IP-OA, at least in patients with advanced hip or knee OA.
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Abbreviations
- OA:
-
Osteoarthritis
- CMC:
-
Carpometacarpal
- IP:
-
Interphalangeal
- DIP:
-
Distal interphalangeal
- PIP:
-
Proximal interphalangeal
- JSN:
-
Joint space narrowing
References
Van Saase JL, Van Romunde LKJ, Cats A, Vandenbroucke JP, Valkenburg HA (1989) Epidemiology of osteoarthritis: Zoetermeer survey. Ann Rheum Dis 48:271–280
Cushnaghan J, Dieppe P (1991) Study of 500 patients with limb joint osteoarthritis. I. Analysis by age, sex, and distribution of symptomatic joint sites. Ann Rheum Dis 50: 8–13
Kessler S, Dieppe P, Fuchs J, Stuermer T, Guenther KP (2000) Assessing the prevalence of hand osteoarthritis in epidemiological studies. The reliability of a radiological hand scale. Ann Rheum Dis 59: 289–292
Egger P, Cooper C, Hart DJ, Doyle DV, Coggon D, Spector TD (1995) Patterns of joint involvement in osteoarthritis of the hand: the Chingford Study. J Rheumatol 22: 1509–1513
Kallman DA, Wigley FM, Scott WW Jr, Hochberg MC, Tobin JD (1990) The longitudinal course of hand osteoarthritis in a male population. Arthritis Rheum 33:1323–1332
Plato CH, Norris A (1979) Osteoarthritis of the hand: Longitudinal studies. Am J Epidemiol 110: 740–746
Dieppe P (1984) Osteoarthritis: are we asking the wrong question? Br J Rheumatol 23:161–165
Hadler NM, Gillings DB, Imbus HR et al. (1978) . Hand structure and function in an industrial setting. Arthritis-Rheum 2: 210–220
Davis M (1988) Epidemiology of osteoarthritis. Clin Geriatr Med 4: 241–255
Peyron JG (1979) Epidemiologic and etiologic approach of osteoarthritis. Semin Arthritis Rheum 8:288–306
Peyron JG (1986) Osteoarthritis: The epidemiologic viewpoint. Clin Orthop 213:9-13
Spector TD, Cicuttini F, Baker J, Loughlin J, Hart D (1996) Genetic influences on osteoarthritis in women: a twin study. Br Med J 312: 940–943
Guenther KP, Stürmer T, Sauerland S et al. (1998) Prevalence of generalized osteoarthritis in patients with degenerative disease of hip and knee joints: the Ulm osteoarthritis study. Ann Rheum Dis 57:717–723
Altman RD, Hochberg M, Murphy W, Wolfe F, Lequesne M (1995) Atlas of individual radiographic features in osteoarthritis. Osteoarthritis Cartilage 3(Suppl A):3–70
Kellgren JH, Lawrence JS (1957) Radiological assessment of osteoarthritis. Ann Rheum Dis 16:494–501
Kellgren JH, Lawrence JS (1963) Atlas of standard radiographs: the epidemiology of chronic rheumatism, Vol 2. Oxford: Blackwell Scientific Publications
Lawrence JS, Bremner JM, Biers F (1966) Osteoarthritis. Prevalence in the population and relationship between symtoms and x-ray chages. Ann Rheum Dis 25:1–5
Lawrence JS (1977) Rheumatism in populations. London, Heinemann
Aspelund G, Gunnarsdottir S, Jonsson P, Jonsson H (1996) Hand osteoarthritis in the elderly. Scand J Rheumatol 25:34–36
Cushnaghan J, Dieppe P (1991) Study of 500 patients with limb joint osteoarthritis. I. Analysis by age, sex, and distribution of symptomatic joint sites. Ann Rheum Dis 50: 8–13
Spector TD, Hart DJ, Brown P et al. (1991). Frequency of osteoarthritis in hysterectomized women. J Rheumatol 18: 1877–1883
Davis MA, Neuhaus JM, Ettinger WH, Muller WH (1990) Body fat distribution and osteoarthritis. Am J Epidemiol 132:701–707
Bagge E, Bjelle A, Eden S, Svanborg A (1991) Factors associated with radiographic osteoarthritis: results from the population study of 70-year-old people in Goteborg. J Rheumatol 18:1218–1222
Hart DJ, Spector TD (1993) The relationship of obesity, fat distribution and osteoarthritis in women in the general population: The Chingford study. J Rheumatol 20:331–335
Sowers M, Zobel D, Weissfeld L, Hawthorne VM, Carman W (1991) Progression of osteoarthritis of the hand and metacarpal bone loss. A twenty-year followup of incident cases. Arthritis Rheum 34: 36–42
Hochberg MC, Lethbridge-Cejku M, Plato CC, Wigley FM, Tobin JD (1991) Factors associated with osteoarthritis of the hand in males: data from the Baltimore Longitudinal Study of Aging. Am J Epidemiol 134:1121–1127
Lawrence JS (1961) Rheumatism in cotton operatives. Br J Indust Med 18:270–276
Dieppe P (1994) Osteoarthritis. In: Klippel J, Dieppe P, eds. Rheumatology. London, Mosby Year Book-Europe
Lawrence JS (1975) Hypertension in relation to musculoskeletal disorders. Ann Rheum Dis 74:451–456
Waine H, Nevinny D, Rosenthal J (1961) Association of osteoarthritis and diabetes mellitus. Tufts Folia Med 7:13–19
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Kessler, S., Stöve, J., Puhl, W. et al. First carpometacarpal and interphalangeal osteoarthritis of the hand in patients with advanced hip or knee OA. Are there differences in the aetiology?. Clin Rheumatol 22, 409–413 (2003). https://doi.org/10.1007/s10067-003-0783-5
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DOI: https://doi.org/10.1007/s10067-003-0783-5