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Evaluations for surrounding tissue incorporation after implantation of synthetic vascular prostheses in animal models

  • Original Article
  • Blood Vessel Prosthesis
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Abstract

Incorporation of surrounding tissues after implantation of synthetic vascular prostheses potentially varies in accordance with implanted prostheses. To evaluate post-implant tissue incorporation, we examined surgical, histological and ultrastructural findings after implantation in animal models. Three types of commercially available prostheses were tested (Gelweave™; Group G, J Graft SHIELD NEO®; Group J and Triplex®; Group T). Prostheses were implanted into Sprague–Dawley rats subcutaneously or sutured on abdominal aorta of Japanese white rabbits. The tissues were surgically examined for adhesion and were subjected to histological evaluations for cellular and tissue infiltration and ultrastructural observations by scanning electron microscopy (SEM). Group G exhibited less tendency in adhesion formation in early phase (rat: G vs J, P < 0.0001; G vs T, P < 0.0001/rabbit: G vs J, P < 0.0001; G vs T, P = 0.059). In late phase, Group J showed highest adhesion (rat: G vs J, P = 0.0004; J vs T, P = 0.015/rabbit: G vs J, P = 0.0015; J vs T, P = 0.0044). In group G, a gap was observed between implants and surrounding tissues forming capsulation, whereas other groups exhibited tissue infiltration inside of the implants wall which were also confirmed by SEM. The tissue permeation toward the implants and adhesion was positively correlated (P < 0.0001). Surrounding tissue conformation varied in accordance with the type of prostheses. It is desirable to elucidate characteristics of each prosthesis to select suitable grafts for each patient to achieve a better surgical outcome.

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Acknowledgements

The authors thank Mr. Shuichi Miyake, Ms. Yasuyo Matsubara, Mr. Haruyasu Koda and Ms. Keiko Furuta (Kyoto University) for the technical support. This work was supported by collaborative research grants from Terumo Corp. and Japan Lifeline Co. Ltd, and Invited Research Project of Institute for Advancement of Clinical Transnational Science, Kyoto University Hospital (to Kenji Minatoya).

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  1. Shingo Hirao

    Present address: Department of Cardiovascular Surgery, Kurashiki Central Hospital, Kurashiki, Japan

Authors and Affiliations

  1. Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan

    Yasue Fujiwara, Shingo Hirao, Kazuhiro Yamazaki, Tadashi Ikeda, Kenji Minatoya & Hidetoshi Masumoto

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  1. Yasue Fujiwara
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  2. Shingo Hirao
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  3. Kazuhiro Yamazaki
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Contributions

KM and HM contributed to the study conception and design. Material preparation, data collection and analysis were performed by YF, SH and HM. Data analyses were performed by KY and TI. The first draft of the manuscript was written by YF and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Hidetoshi Masumoto.

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Fujiwara, Y., Hirao, S., Yamazaki, K. et al. Evaluations for surrounding tissue incorporation after implantation of synthetic vascular prostheses in animal models. J Artif Organs 25, 24–33 (2022). https://doi.org/10.1007/s10047-021-01283-3

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  • DOI: https://doi.org/10.1007/s10047-021-01283-3

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