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Development of novel covered stents using salmon collagen

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Abstract

In this study, we newly developed self-expandable or balloon-expandable covered stents with a biodegradable salmon collagen (SC) film. The SC-covered stents were fabricated by placing a bare stent in a mixture of acidic SC solution and a fibrillogenesis-inducing buffer (pH 6.8) including a cross-linking agent (water-soluble carbodiimide), and subsequent incubation at 4°C for 24 h and lyophilization. The stents obtained were completely covered with an SC film having a nanofibrous structure (fibril diameter, about 70 nm). On immersion in water, the film is converted to a gel with slight swelling. There was no rupture of the SC cover after mounting on a balloon catheter or after expansion. Preliminary implantation was conducted by placing the balloon-expandable covered stents in the common carotid arteries of beagles. One month after implantation, angiography showed that all stented arteries were patent with no significant neointimal thickening. In conclusion, SC is potentially useful as a cover material of endovascular stents to enhance patency.

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Authors and Affiliations

  1. Creative Research Initiative “Sousei” (CRIS), Hokkaido University, N21-W10, Kita-ku, Sapporo, 001-0021, Japan

    Nobuhiro Nagai

  2. Department of Bioengineering, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Osaka, Japan

    Yasuhide Nakayama

  3. Division of Biotechnology and Macromolecular Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo, Japan

    Yasuhide Nakayama & Masanobu Munekata

  4. Department of Neurosurgery, Sapporo Higashi-Tokushukai Hospital, Sapporo, Japan

    Shogo Nishi

Authors
  1. Nobuhiro Nagai
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  2. Yasuhide Nakayama
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  3. Shogo Nishi
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  4. Masanobu Munekata
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Correspondence to Nobuhiro Nagai.

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Nagai, N., Nakayama, Y., Nishi, S. et al. Development of novel covered stents using salmon collagen. J Artif Organs 12, 61–66 (2009). https://doi.org/10.1007/s10047-008-0446-z

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  • DOI: https://doi.org/10.1007/s10047-008-0446-z

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