Abstract
The 1555A?G point mutation is associated with a susceptibility to aminoglycoside antibiotics, and is of particular interest, as it may cause hearing loss even without aminoglycoside exposure. There may be a considerably large high-risk population in Japan, and to avoid possible side effects in this group, a rapid mass screening system and careful counseling are recommended. We are currently using the mutant allele specific amplification (MASA) method to detect the 1555A?G mitochondrial mutation and we distribute a warning card to subjects found to bear this mutation.
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Received: March 25, 1999 / Accepted: April 16, 1999
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Usami, S., Abe, S., Shinkawa, H. et al. Rapid mass screening method and counseling for the 1555A?G mitochondrial mutation. J Hum Genet 44, 304–307 (1999). https://doi.org/10.1007/s100380050165
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DOI: https://doi.org/10.1007/s100380050165
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