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Prevalence of dental alterations in patients under bisphosphonates therapy: a systematic review

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Abstract

This systematic review aimed to estimate the prevalence and describe dentoalveolar lesions associated with bisphosphonates therapy. A systematic review of the literature was conducted using the following databases: PubMed, Embase, Cochrane, CINAHL, Scopus, Web of Science, Lilacs, SciElo, and Grey Literature. Quality of individual studies analysis was performed by using Newcastle–Ottawa Scale. Certainty of cumulative evidence was achieved by applying Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria. The software R Statistics version 4.0.5 (The R Foundation) was used for proportion estimations per study and corresponding confidence intervals were estimated through the Clopper-Pearson method. Four articles were included for the qualitative synthesis. Two studies were considered of good quality, one of fair, and one of poor quality. A total of 231 patients were encompassed. Widening of the periodontal ligament space (22.2–39.7%), periradicular radiolucencies (20–22.9%), and pulp calcifications (33.3–69.2%) were the most frequent alterations. Certainty of evidence was rated as very low. Based on limited evidence, this systematic review reports a variety of dentoalveolar alterations in patients under bisphosphonate therapy. These features might impact on dental clinical practice. However, the level of evidence is considered very low due to important limitations.

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Data availability

The data that support the findings of this study are available from the corresponding author, RG, upon reasonable request.

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Authors and Affiliations

  1. Dentistry School, Health Sciences Center, Federal University of Santa Catarina, Florianopolis, SC, Brazil

    Monique Abreu Pauli

  2. Health Sciences Center, Post-Graduate Program in Dentistry, Federal University of Santa Catarina, Florianopolis, SC, Brazil

    Natália Cristina Trentin Bordignon & Geórgia Ribeiro Martini

  3. Department of Dentistry, Oncology Research Center, Florianopolis, SC, Brazil

    Mariana Comparotto Minamisako

  4. Department of Pathology, Health Sciences Center, Federal University of Santa Catarina, Delfino Conti St. Trindade, Florianopolis, SC, 88040-370, Brazil

    Rogério Gondak

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  2. Natália Cristina Trentin Bordignon
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  3. Geórgia Ribeiro Martini
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  4. Mariana Comparotto Minamisako
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Contributions

MAP, data collection, data analysis, interpretation and paper drafting; NCTB, data collection, data analysis, and interpretation; GRM, interpretation and critical revision of the article; MCM, study design, interpretation, and critical revision of the article. RG, conception, study design, critical revision of the article. All authors have approved the submitted final version.

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Correspondence to Rogério Gondak.

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Pauli, M.A., Bordignon, N.C.T., Martini, G.R. et al. Prevalence of dental alterations in patients under bisphosphonates therapy: a systematic review. Oral Maxillofac Surg 27, 399–409 (2023). https://doi.org/10.1007/s10006-022-01084-9

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