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Solitary fibrous tumor of soft tissue: a case report and immunohistochemical study

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Abstract

A case of solitary fibrous tumor (SFT) arising in the soft tissue of the left inguinal region is reported. A 57-year-old Japanese woman presented with a nonadherent, well-defined, oval mass that was 2 × 3 cm in diameter and located in the inguinal soft tissue. Microscopic evaluation showed proliferation of spindle-shaped, fibroblast-like cells by the coexistence of hypo- and hypercellular areas with mast cell infiltration separated by hemangiopericytoma-like blood vessels. Immunohistochemistry revealed strong expression of CD34 and CD99 in the fibroblast-like cells, supporting the diagnosis of SFT. Although the patient was free of symptoms such as hypoglycemia, immunoreactive insulin-like growth factor (IGF)-II was localized in the socalled Golgi area of the spindle-shaped cells. In conclusion, immunoreactive IGF-II was detected in SFT that was not associated with hypoglycemia.

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Authors and Affiliations

  1. Department of Pathology II, Kansai Medical University, Moriguchi. Osaka, Japan

    Takashi Yuri, Sayaka Kanematsu, Yen-Chang Lei, Maki Kuwata & Airo Tsubura

  2. Division of Surgery, Kansai Medical University Takii Hospital, Osaka, Japan

    Masaharu Oishi

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  1. Takashi Yuri
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  2. Sayaka Kanematsu
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  3. Yen-Chang Lei
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  4. Maki Kuwata
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  5. Masaharu Oishi
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  6. Airo Tsubura
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Correspondence to Takashi Yuri.

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Yuri, T., Kanematsu, S., Lei, YC. et al. Solitary fibrous tumor of soft tissue: a case report and immunohistochemical study. Med Mol Morphol 43, 60–64 (2010). https://doi.org/10.1007/s00795-009-0451-1

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  • DOI: https://doi.org/10.1007/s00795-009-0451-1

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