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P57kip2 immunohistochemical expression and ultrastructural findings of gestational trophoblastic disease and related disorders

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Abstract

Gestational trophoblastic disease (GTD) is a unique spectrum of diseases ranging from complete hydatidiform mole (CHM), partial hydatidiform mole (PHM), and invasive mole (IM) to choriocarcinoma (CC). Placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT) have been classified as related disorders. Mesenchymal dysplasia (MD) may be misdiagnosed as PHM; however, it is said to have a quite different histogenesis from PHM. P57kip2 is the protein product of a paternally imprinted or maternal gene that inhibits cyclin-dependent kinases (CDK), thus serving to inhibit cell proliferation and to suppress tumor growth. Its lack of expression in trophoblastic disease plays a role in its abnormal proliferation and differentiation. In this study, P57kip2 immunostaining was absent in the trophoblastic layers of CHM and was positive in the trophoblast layer of nonmolar villi and MD. Ultrastructure of complete molar cystic villi showed tree-like branching of microvillous processes and intracytoplasmic lacunae without capillaries in the stroma, whereas MD contained many newly formed blood vessels and collagen. Also, large lacunae with microvilli and polymorphic nuclei of syncytiotrophoblast cells with well-developed organelles were observed in IM. Lung ETT following CHM and normal deliveries showed two types of large mononuclear cells and binuclear cells with abundant organelles and bundles of intermediate-type filaments in the stroma.

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Author notes

  1. Hiroaki Soma

    Present address: , 1-4-11 Kyodo, Setagaya-ku, Tokyo, 156-0052, Japan

Authors and Affiliations

  1. Department of Obstetrics & Gynecology, Saitama Medical School, 38 Morohongo, Moroyama-cho, Iruma-gun, Saitama, 350-0495, Japan

    Hiroaki Soma & Hiroyuki Osawa

  2. Nihon Medical School, Chiba Hokuso Hospital, Chiba, Japan

    Tatsuo Oguro

  3. Electron Microscopy Section, Tokyo Medical University, Shinjuku, Tokyo, Japan

    Isao Yoshihama

  4. Department of Pathology, Tokyo Medical University, Shinjuku, Tokyo, Japan

    Koji Fujita, Shoichiro Mineo & Motoshige Kudo

  5. Division of Morphological Science, Biomedical Center, Saitama Medical School, Saitama, Japan

    Kayoko Tanaka & Masumi Akita

  6. Department of Obstetrics & Gynecology, Hiroshima University, Hiroshima, Japan

    Satoshi Urabe & Yoshiki Kudo

Authors
  1. Hiroaki Soma
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  2. Hiroyuki Osawa
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  3. Tatsuo Oguro
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  8. Kayoko Tanaka
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  9. Masumi Akita
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  10. Satoshi Urabe
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Correspondence to Hiroaki Soma.

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Soma, H., Osawa, H., Oguro, T. et al. P57kip2 immunohistochemical expression and ultrastructural findings of gestational trophoblastic disease and related disorders. Med Mol Morphol 40, 95–102 (2007). https://doi.org/10.1007/s00795-007-0362-y

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  • DOI: https://doi.org/10.1007/s00795-007-0362-y

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