Abstract
The literature on subclinical autism spectrum (ASD) symptoms in pediatric obsessive–compulsive disorder (OCD) is scarce, and it remains unclear whether ASD symptoms are related to OCD severity. The aims of the present study were to assess the prevalence of ASD symptoms and age and sex differences in children and adolescents with OCD, and to explore the relation between ASD symptoms and OCD severity. This is the largest study of ASD symptoms in an OCD population to date, and the first directly aimed at elucidating sex and age differences in this matter. The study used baseline data from the Nordic Long-term OCD Treatment Study in which parents of 257 children and adolescents with OCD aged 7–17 completed the Autism Spectrum Screening Questionnaire. OCD severity was assessed with the Children’s Yale–Brown Obsessive Compulsive Scale. Pediatric OCD patients were found to exhibit elevated rates of ASD symptoms compared to a norm group of school-age children. ASD symptoms were concentrated in a subgroup with a prevalence of 10–17 %. This subgroup was characterized by a male preponderance with a sex ratio of approximately 2.6:1, while children versus adolescents with OCD exhibited similar rates. Autism-specific social and communication difficulties were not related to OCD severity, while restricted repetitive behavior was positively related to OCD severity. The results indicate that clinicians need to be aware of ASD symptoms in children and adolescents with OCD since one out of ten exhibits such symptoms at a clinical sub-threshold.
Similar content being viewed by others
References
American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric, Arlington
Canals J, Hernández-Martínez C, Cosi S, Voltas N (2012) The epidemiology of obsessive–compulsive disorder in Spanish school children. J Anxiety Disord 26:746–752. doi:10.1016/j.janxdis.2012.06.003
Rapoport JL, Inoff-Germain G, Weissman MM, Greenwald S, Narrow WE, Jensen PS, Lahey BB, Canino G (2000) Childhood obsessive–compulsive disorder in the NIMH MECA Study: parent versus child identification of cases. J Anxiety Disord 14:535–548. doi:10.1016/S0887-6185(00)00048-7
Ivarsson T, Melin K, Wallin L (2008) Categorical and dimensional aspects of co-morbidity in obsessive–compulsive disorder (OCD). Eur Child Adolesc Psychiatry 17:20–31. doi:10.1007/s00787-007-0626-z
Mack H, Fullana MA, Russell AJ, Mataix-Cols D, Nakatani E, Heyman I (2010) Obsessions and compulsions in children with Asperger’s syndrome or high-functioning autism: a case–control study. Aust N Z J Psychiatry 44:1082–1088. doi:10.3109/00048674.2010.515561
Ivarsson T, Melin K (2008) Autism spectrum traits in children and adolescents with obsessive–compulsive disorder (OCD). J Anxiety Disord 22:969–978. doi:10.1016/j.janxdis.2007.10.003
Huang L, Tsai K, Wang H, Sung P, Wu M, Hung K, Lin S (2014) Prevalence, incidence, and comorbidity of clinically diagnosed obsessive–compulsive disorder in Taiwan: a national population-based study. Psychiatry Res 220:335–341. doi:10.1016/j.psychres.2014.08.011
Lai M, Lombardo MV, Baron-Cohen S (2014) Autism. The Lancet 383:896–910. doi:10.1016/S0140-6736(13)61539-1
Weidle B, Melin K, Drotz E, Jozefiak T, Ivarsson T (2012) Preschool and current autistic symptoms in children and adolescents with obsessive–compulsive disorder (OCD). J Obsessive Compuls Relat Disord 1:168–174. doi:10.1016/j.jocrd.2012.04.002
Anholt GE, Cath DC, van Oppen P, Eikelenboom M, Smit J, van Megen H, van Balkom AJLM (2010) Autism and ADHD symptoms in patients with OCD: are they associated with specific OC symptom dimensions or OC symptom severity? J Autism Dev Disord 40:580–589. doi:10.1007/s10803-009-0922-1
Bejerot S, Nylander L, Lindstrom E (2001) Autistic traits in obsessive–compulsive disorder. Nord J Psychiatry 55:169–176. doi:10.1080/08039480152036047
Mito H, Matsuura N, Mukai K, Yanagisawa Y, Nakajima A, Motoyama M, Arikawa A, Yamanishi K, Matsunaga H (2014) The impacts of elevated autism spectrum disorder traits on clinical and psychosocial features and long-term treatment outcome in adult patients with obsessive–compulsive disorder. Compr Psychiatry 55:1526–1533. doi:10.1016/j.comppsych.2014.05.005
Bejerot S (2007) An autistic dimension: a proposed subtype of obsessive–compulsive disorder. Autism 11:101–110. doi:10.1177/1362361307075699
Mattila M, Jussila K, Kuusikko S, Kielinen M, Linna S, Ebeling H, Bloigu R, Joskitt L, Pauls D, Moilanen I (2009) When does the Autism Spectrum Screening Questionnaire (ASSQ) predict autism spectrum disorders in primary school-aged children? Eur Child Adolesc Psychiatry 18:499–509. doi:10.1007/s00787-009-0044-5
Posserud M, Lundervold AJ, Gillberg C (2006) Autistic features in a total population of 7–9-year-old children assessed by the ASSQ (Autism Spectrum Screening Questionnaire). J Child Psychol Psychiatry 47:167–175. doi:10.1111/j.1469-7610.2005.01462.x
Constantino JN, Todd RD (2003) Autistic traits in the general population: a twin study. Arch Gen Psychiatry 60:524–530. doi:10.1001/archpsyc.60.5.524
Paula-Pérez I (2013) Differential diagnosis between obsessive compulsive disorder and restrictive and repetitive behavioural patterns, activities and interests in autism spectrum disorder. Rev Psiquiatr Salud Ment 6:178–186. doi:10.1016/j.rpsm.2012.07.005
Zandt F, Prior M, Kyrios M (2007) Repetitive behaviour in children with high functioning autism and obsessive compulsive disorder. J Autism Dev Disord 37:251–259. doi:10.1007/s10803-006-0158-2
Cath DC, Ran N, Smit JH, van Balkom AJLM, Comijs HC (2008) Symptom overlap between autism spectrum disorder, generalized social anxiety disorder and obsessive–compulsive disorder in adults: a preliminary case–controlled study. Psychopathology 41:101–110. doi:10.1159/000111555
Hartley SL, Sikora DM (2009) Which DSM-IV-TR criteria best differentiate high-functioning autism spectrum disorder from ADHD and anxiety disorders in older children? Autism 13:485–509. doi:10.1177/1362361309335717
Bartz JA, Hollander E (2006) Is obsessive–compulsive disorder an anxiety disorder? Prog Neuropsychopharmacol Biol Psychiatry 30:338–352. doi:10.1016/j.pnpbp.2005.11.003
Jacob S, Landeros-Weisenberger A, Leckman JF (2009) Autism spectrum and obsessive–compulsive disorders: OC behaviors, phenotypes and genetics. Autism Res 2:293–311. doi:10.1002/aur.108
Langley AK, Lewin AB, Bergman RL, Lee JC, Piacentini J (2010) Correlates of comorbid anxiety and externalizing disorders in childhood obsessive compulsive disorder. Eur Child Adolesc Psychiatry 19:637–645. doi:10.1007/s00787-010-0101-0
Storch EA, Larson MJ, Merlo LJ, Keeley ML, Jacob ML, Geffken GR, Murphy TK, Goodman WK (2008) Comorbidity of pediatric obsessive–compulsive disorder and anxiety disorders: impact on symptom severity and impairment. J Psychopathol Behav Assess 30:111–120. doi:10.1007/s10862-007-9057-x
Gothelf D, Goraly O, Avni S, Stawski M, Hartmann I, Basel-Vanagaite L, Apter A (2008) Psychiatric morbidity with focus on obsessive–compulsive disorder in an Israeli cohort of adolescents with mild to moderate mental retardation. J Neural Transm 115:929–936. doi:10.1007/s00702-008-0037-4
Lewin AB, Wood JJ, Gunderson S, Murphy TK, Storch EA (2011) Phenomenology of comorbid autism spectrum and obsessive–compulsive disorders among children. J Dev Phys Disabil 23:543–553. doi:10.1007/s10882-011-9247-z
Thomsen PH, Torp NC, Dahl K, Christensen K, Englyst I, Melin KH, Nissen JB, Hybel KA, Valderhaug R, Weidle B, Skarphedinsson G, von Bahr PL, Ivarsson T (2013) The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods. Child Adolesc Psychiatry Ment Health. doi:10.1186/1753-2000-7-41
Torp NC, Dahl K, Skarphedinsson G, Thomsen PH, Valderhaug R, Weidle B, Melin KH, Hybel K, Nissen JB, Lenhard F, Wentzel-Larsen T, Franklin ME, Ivarsson T (2015) Effectiveness of cognitive behavior treatment for pediatric obsessive–compulsive disorder: acute outcomes from the Nordic Long-term OCD Treatment Study (NordLOTS). Behav Res Ther 64:15–23. doi:10.1016/j.brat.2014.11.005
American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, 4th edn., text rev. American Psychiatric, Washington
Ehlers S, Gillberg C (1993) The epidemiology of Asperger syndrome: a total population study. J Child Psychol Psychiat 34:1327–1350. doi:10.1111/j.1469-7610.1993.tb02094.x
Ehlers S, Gillberg C, Wing L (1999) A screening questionnaire for Asperger syndrome and other high-functioning autism spectrum disorders in school age children. J Autism Dev Disord 29:129–141. doi:10.1023/A:1023040610384
Posserud M, Lundervold AJ, Gillberg C (2009) Validation of the Autism Spectrum Screening Questionnaire in a total population sample. J Autism Dev Disord 39:126–134. doi:10.1007/s10803-008-0609-z
Posserud M, Lundervold AJ, Steijnen MC, Verhoeven S, Stormark KM, Gillberg C (2008) Factor analysis of the Autism Spectrum Screening Questionnaire. Autism 12:99–112. doi:10.1177/1362361307085268
Kaufman J, Birmaher B (1997) Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980–988
Birmaher B, Ehmann M, Axelson DA, Goldstein BI, Monk K, Kalas C, Kupfer D, Gill MK, Leibenluft E, Bridge J, Guyer A, Egger HL, Brent DA (2009) Schedule for Affective Disorders and Schizophrenia for school-age children (K-SADS-PL) for the assessment of preschool children—a preliminary psychometric study. J Psychiatr Res 43:680–686. doi:10.1016/j.jpsychires.2008.10.003
Scahill L, Riddle MA, McSwiggin-Hardin M, Ort SI, King RA, Goodman WK, Cicchetti D, Leckman JF (1997) Children’s Yale–Brown Obsessive Compulsive Scale: reliability and validity. J Am Acad Child Adolesc Psychiatry 36:844–852. doi:10.1097/00004583-199706000-00023
Storch EA, Murphy TK, Geffken GR, Soto O, Sajid M, Allen P, Roberti JW, Killiany EM, Goodman WK (2004) Psychometric evaluation of the Children’s Yale–Brown Obsessive–Compulsive Scale. Psychiatry Res 129:91–98. doi:10.1016/j.psychres.2004.06.009
Cicchetti DV, Sparrow SS (1990) Assessment of adaptive behavior in young children. In: Johnson JJ, Goldman J (eds) Developmental assessment in clinical child psychology: a handbook. Pergamon Press, New York, pp 173–196
Cohen J (1988) Statistical power analysis for the behavioral sciences. Erlbaum, Hillsdale
Kopp S, Gillberg C (2011) The Autism Spectrum Screening Questionnaire (ASSQ)—Revised Extended Version (ASSQ-REV): an instrument for better capturing the autism phenotype in girls? A preliminary study involving 191 clinical cases and community controls. Res Dev Disabil 32:2875–2888. doi:10.1016/j.ridd.2011.05.017
Reiersen AM, Constantino JN, Volk HE, Todd RD (2007) Autistic traits in a population-based ADHD twin sample. J Child Psychol Psychiatry 48:464–472. doi:10.1111/j.1469-7610.2006.01720.x
AACAP (2012) Practice parameter for the assessment and treatment of children and adolescents with obsessive–compulsive disorder. J Am Acad Child Adolesc Psychiatry 51:98–113. doi:10.1016/j.jaac.2011.09.019
Hollander E, King A, Delaney K, Smith CJ, Silverman JM (2003) Obsessive–compulsive behaviors in parents of multiplex autism families. Psychiatry Res 117:11–16. doi:10.1016/S0165-1781(02)00304-9
Van Wijngaarden-Cremers PJM, van Eeten E, Groen WB, Van Deurzen PA, Oosterling IJ, Van der Gaag RJ (2014) Gender and age differences in the core triad of impairments in autism spectrum disorders: a systematic review and meta-analysis. J Autism Dev Disord 44:627–635. doi:10.1007/s10803-013-1913-9
Kreiser NL, White SW (2014) ASD in females: are we overstating the gender difference in diagnosis? Clin Child Fam Psychol Rev 17:67–84. doi:10.1007/s10567-013-0148-9
Rivet TT, Matson JL (2011) Review of gender differences in core symptomatology in autism spectrum disorders. Res Autism Spectr Disord 5:957–976. doi:10.1016/j.rasd.2010.12.003
McKay D, Abramowitz JS, Calamari JE, Kyrios M, Radomsky A, Sookman D, Taylor S, Wilhelm S (2004) A critical evaluation of obsessive–compulsive disorder subtypes: symptoms versus mechanisms. Clin Psychol Rev 24:283–313. doi:10.1016/j.cpr.2004.04.003
Acknowledgments
We want to thank the patients, their parents, the clinics, and therapists that participated in the NordLOTS. The present study was funded with support by the Research Foundation for Center for Child and Adolescent Psychiatry, Central Denmark Region.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethics
National committees for Medical and Health Research in Denmark, Norway, and Sweden approved the NordLOTS. Parents and children/adolescents received oral and written information about the study, and written informed consent was obtained from parent(s) or legal guardian(s), and from children of 11 years or older before inclusion in the study.
Rights and permissions
About this article
Cite this article
Arildskov, T.W., Højgaard, D.R.M.A., Skarphedinsson, G. et al. Subclinical autism spectrum symptoms in pediatric obsessive–compulsive disorder. Eur Child Adolesc Psychiatry 25, 711–723 (2016). https://doi.org/10.1007/s00787-015-0782-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00787-015-0782-5