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Comparison of the effect of therapeutic elastic bandage, submucosal dexamethasone, or dexketoprofen trometamol on inflammatory symptoms and quality of life following third molar surgery: a randomized clinical trial

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Abstract

Objectives

We aimed to compare the effects of preoperative single-dose submucosal corticosteroid injection and postoperative elastic therapeutic bandage application with postoperative non-steroid anti-inflammatory drug therapy on postoperative inflammatory symptoms and quality of life following mandibular third molar surgeries.

Materials and methods

A single-center, randomized, clinical trial was conducted with 52 patients (36 female, 16 male) who expected severe postoperative sequelae as a result of the extraction of impacted mandibular third molars. The patients were randomized into three groups. In the preoperative submucosal corticosteroid injection group (n = 16), 8 mg/2 ml dexamethasone 21-phosphate was administered near operated sites. In the postoperative therapeutic elastic bandage application group (n = 19), Kinesio tapes were applied to operated sites. Paracetamol 500 mg was prescribed for the patients in the corticosteroid and elastic bandage application groups. In the postoperative non-steroid anti-inflammatory drug group (n = 17), 25 mg dexketoprofen trometamol was prescribed. Maximal mouth opening, swelling, pain, and Oral Health Impaction Profile scores were quantified preoperatively and postoperatively on the second and seventh days. Additionally, all patients were asked to evaluate the postoperative period by the Postoperative Symptom Severity Scale.

Results

Analysis of the obtained data revealed that on the second postoperative day, postoperative edema and trismus were significantly lower in the submucosal corticosteroid (p = 0.025, p = 0.03) and therapeutic elastic bandage (p = 0.032, p = 0.014) groups, and the patients in these groups had a more comfortable postoperative period than the group prescribed a postoperative non-steroid anti-inflammatory drug (p = 0.016).

Clinical relevance

In oral surgery, postoperative elastic bandage application can provide results similar to those of preoperative submucosal corticosteroid injection with respect to inflammatory symptoms and quality of life.

Trial registration

ClinicalTrials.gov Identifier: NCT04200885. Date of Registration: December 2019 (retrospectively registered)

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Acknowledgments

The authors thank Prof. Yılmaz ÖZKAN for assistance with statistical analysis.

Funding

None.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tokat Gaziosmanpasa University, Kaleardi Mahallesi, Muhittin Fisunoglu Caddesi, Omcalik Sokak, Ali Sevki Erek Yerleskesi, Dis Hekimligi Fakultesi, Tokat, Turkey

    Aras Erdil, Nihat Akbulut & Ahmet Altan

  2. Private Practice, Arabacialani Mahallesi, Mert Sokak, No: 25, Sakarya, Turkey

    Mustafa Sami Demirsoy

Authors
  1. Aras Erdil
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  2. Nihat Akbulut
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  3. Ahmet Altan
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  4. Mustafa Sami Demirsoy
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Aras Erdil, Nihat Akbulut, Ahmet Altan, and Mustafa Sami Demirsoy. The first draft of the manuscript was written by Aras Erdil and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Aras Erdil.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures were performed in accordance with the ethical standards of our institutional and/or national research committee(s) and those of the 1964 Helsinki declaration and later amendments or comparable ethical standards. The study was approved by the Clinical Researches Ethics Committee of Tokat Gaziosmanpasa University, Faculty of Medicine. (19-KAEK-100)

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Informed consent was obtained from all participants.

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Erdil, A., Akbulut, N., Altan, A. et al. Comparison of the effect of therapeutic elastic bandage, submucosal dexamethasone, or dexketoprofen trometamol on inflammatory symptoms and quality of life following third molar surgery: a randomized clinical trial. Clin Oral Invest 25, 1849–1857 (2021). https://doi.org/10.1007/s00784-020-03487-y

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