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Evaluation of IL-1β, IL-1ra, and IL-10 levels and outcome of periodontal therapy in chronic periodontitis with familial Mediterranean fever

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Abstract

Objectives

This study aimed to examine the IL-1β, IL-1ra, and IL-10 cytokine levels in gingival crevicular fluid (GCF) and serum of familial Mediterranean fever (FMF) and chronic periodontitis (CP) patients, and their response to nonsurgical periodontal therapy.

Materials and methods

A total of 50 patients, 15 FMF patients with generalized chronic periodontitis (FMF-CP), 15 systemically healthy patients with generalized chronic periodontitis (CP), ten systemically and periodontal healthy controls (HC), and ten periodontally healthy FMF patients (FMF-HC) were enrolled in the study. The cytokine levels in GCF and serum were determined by ELISA. Probing depth, clinical attachment level, and gingival and plaque indices in each participant were also measured. The GCF and clinical parameters at baseline and 6 weeks were recorded.

Results

The study indicated statistically significant healing of the clinical parameters in both FMF-CP and CP groups after periodontal treatment. GCF IL-1β levels at 6 weeks in FMF-CP group were significantly lower than the CP group (p < 0.05), and GCF IL-1ra levels were significantly decreased at 6 week in the FMF-CP group (p < 0.05). GCF IL-10 levels were significantly higher in the FMF-CP group than in the other groups at baseline and 6 weeks (p < 0.05). There were no significant differences in serum-IL-1β, IL-1ra, and IL-10 levels either FMF-CP or CP groups at baseline or 6 weeks (p > 0.05).

Conclusions

The results of our study suggested that there was a positive correlation between gingival inflammation and serum cytokine levels in FMF patients and also colchicine treatment showed protective effects on GCF cytokine levels in FMF-CP group.

Clinical relevance

Following treatment, GCF IL-1β and GCF IL-1ra levels were decreased in FMF-CP group. GCF IL-10 levels were increased in FMF-CP group compared to other groups. Also, the serum cytokine levels associated with periodontal inflammation in FMF patients.

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Authors and Affiliations

  1. Department of Periodontology, Cumhuriyet University Faculty of Dentistry, 58140, Sivas, Turkey

    Vildan Bostanci, Hulya Toker, Aysun Akpinar, Emine Pirim Görgün & Olcay Bakar

  2. Department of Rheumatology, Erciyes University Faculty of Medicine, Kayseri, Turkey

    Soner Senel

  3. Department of Microbiology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey

    Omer Poyraz

Authors
  1. Vildan Bostanci
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  2. Hulya Toker
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Correspondence to Vildan Bostanci.

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Funding

This study was funded by the Scientific Research Cumhuriyet University under the project number Dis-124.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Bostanci, V., Toker, H., Senel, S. et al. Evaluation of IL-1β, IL-1ra, and IL-10 levels and outcome of periodontal therapy in chronic periodontitis with familial Mediterranean fever. Clin Oral Invest 21, 469–475 (2017). https://doi.org/10.1007/s00784-016-1816-1

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  • DOI: https://doi.org/10.1007/s00784-016-1816-1

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