Abstract
Extracellular vesicles (EVs) are small particles with lipid bilayer membranes that are secreted by all cell types and are widely known as crucial intercellular communication mediators, shuttling biologically active molecules. The bone is a typically preferred site of cancer metastasis due to its unique cellular compositions and dynamics. Bone cell-derived EVs serve as regulators that orchestrate harmonious bone homeostasis. Cancer cells secrete specific EVs in a series of the bone metastatic process to dominate the bone microenvironment. Additionally, cancer cell-related EVs contribute to pre-metastatic niche formation, bone homeostasis disruption, and tumor bone progression and survival. Here, we investigated recent studies on EV-mediated crosstalk in the bone tumor microenvironment. Furthermore, this review aimed to elucidate the EV-based therapeutic perspectives for bone metastasis.
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The present study was supported in part by Project for Cancer Research and Therapeutic Evolution (P-PROMOTE) grant number: 22ama221405h0001 (to Y.Y.) from the Japan Agency for Medical Research and Development (AMED).
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Tamura, T., Yoshioka, Y., Sakamoto, S. et al. Extracellular vesicles in bone homeostasis: key roles of physiological and pathological conditions. J Bone Miner Metab 41, 345–357 (2023). https://doi.org/10.1007/s00774-022-01362-2
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DOI: https://doi.org/10.1007/s00774-022-01362-2