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Quantitative investigation of the effect of surgically induced hypoparathyroidism on cataract development

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Abstract

Introduction

Although cataract formation is known in hypoparathyroidism, lens clarity and its correlation with clinical parameters have not been investigated quantitatively before in patients with hypoparathyroidism. The aim of this study was to compare the crystalline lens clarity of patients with surgically induced hypoparathyroidism and healthy subjects.

Materials and methods

Forty female patients with surgically induced hypoparathyroidism and 38 age-matched healthy female subjects were enrolled in this study. Scheimpflug corneal topography was performed to measure lens density (LD) and thickness (LT). Serum calcium, inorganic phosphorus, parathyroid hormone (PTH) levels, and disease duration were recorded.

Results

No statistically significant difference was observed between the hypoparathyroidism and control groups in the Pentacam densitometry zones 1–2–3, LT, and average and maximum LD (p > 0.05 for all). Nine blue-dot-like, two cortical, and two posterior subcapsular cataracts were detected in the hypoparathyroidism group. The frequency of total and blue-dot-like cataracts was significantly higher in the hypoparathyroidism group than in the control group (p = 0.008 and p = 0.002, respectively). In the hypoparathyroidism group, a significant correlation was observed between the maximum LD and the hypoparathyroidism duration (ß = 0.420, p = 0.017), and the maximum LD and serum PTH level (ß = −0.332, p = 0.049).

Conclusion

The clarity of the crystalline lens may decrease in surgically induced hypoparathyroidism patients depending on the disease duration and PTH levels. Additionally, this study detected an increased frequency of blue-dot-like cataract in the patient group, which may be due to the effect of hypoparathyroidism.

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Authors and Affiliations

  1. Department of Ophthalmology, Dortyol Public Hospital, Dörtyol, Hatay, Turkey

    Ali Mert Koçer

  2. Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey

    Mehmet Ali Şekeroğlu, Seda Çevik, Furkan Emre Söğüt & Sibel Doğuizi

  3. Department of Endocrinology, Ankara Training and Research Hospital, Ankara, Turkey

    Çağatay Emir Önder & Şerife Mehlika Kuşkonmaz

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  1. Ali Mert Koçer
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Contributions

AMK, MAS, and SMK were responsible for designing and conducting the study. SC, FES, CEO, and SMK performed the data collection. MAS analyzed the data. SD contributed equipment/materials. AMK and MAS wrote the paper. All authors approved the fnal version.

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Correspondence to Ali Mert Koçer.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Koçer, A.M., Şekeroğlu, M.A., Önder, Ç.E. et al. Quantitative investigation of the effect of surgically induced hypoparathyroidism on cataract development. J Bone Miner Metab 40, 92–100 (2022). https://doi.org/10.1007/s00774-021-01257-8

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  • DOI: https://doi.org/10.1007/s00774-021-01257-8

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