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Reduction of visceral fat could be related to the improvement of TBS in diabetes mellitus

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Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Introduction

Diabetes has been proposed as a risk factor for increased skeletal fragility. Visceral fat is known to yield adverse effects on bone metabolism in people with diabetes. We investigated the relationship between the change in visceral fat mass over time and TBS or BMD.

Materials and methods

This retrospective study enrolled 690 (male: 367; female: 323) subjects with type 2 diabetes mellitus. Visceral fat mass, lumbar and femoral neck BMD, and lumbar spine TBS were measured via dual-energy X-ray absorptiometry (DXA), including the follow-up data within a 3-year period.

Results

TBS significantly increased as visceral fat mass decreased in both sexes (p < 0.001), whereas lumbar BMD and femoral neck BMD showed meaningful changes only in men. The multiple regression model with adjustment for age, weight, creatinine level, lipid profile, HbA1C, and status of osteoporosis medication use revealed that TBS and femoral neck BMD were correlated with visceral fat mass. However, regarding longitudinal changes, only the change in visceral fat mass had a significant relationship with TBS (males: β = − 0.298, p < 0.001; females: β = − 0.216, p < 0.001).

Conclusions

The results of this study may suggest the beneficial effect of controlling visceral fat mass on bone health in type 2 diabetes patients. Besides, DXA-derived TBS could be a useful diagnostic tool for evaluating the bone changes according to metabolic changes in type 2 diabetes, which are not entirely achieved with BMD.

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, South Korea

    Hyun Uk Moon, Nami Lee, Yoon-Sok Chung & Yong Jun Choi

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  1. Hyun Uk Moon
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  2. Nami Lee
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  3. Yoon-Sok Chung
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  4. Yong Jun Choi
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Correspondence to Yong Jun Choi.

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Moon, H.U., Lee, N., Chung, YS. et al. Reduction of visceral fat could be related to the improvement of TBS in diabetes mellitus. J Bone Miner Metab 38, 702–709 (2020). https://doi.org/10.1007/s00774-020-01107-z

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  • DOI: https://doi.org/10.1007/s00774-020-01107-z

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