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Effects of risedronate alone or combined with vitamin K2 on serum undercarboxylated osteocalcin and osteocalcin levels in postmenopausal osteoporosis

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Abstract

Risedronate decreases osteoporotic fracture incidence; however, its effects remain unclear in elderly osteoporotic patients. Vitamin K mediates carboxylation of osteocalcin (OC), and high undercarboxylated osteocalcin (ucOC) levels indicate vitamin K deficiency and increased osteoporotic fracture risk. We aimed to evaluate the effects of risedronate alone or combined with vitamin K2 on serum ucOC, OC, and incidence of vertebral fractures in elderly osteoporotic patients. A total of 101 women with postmenopausal osteoporosis aged >60 years were randomly stratified into two groups—R group (n = 51), treated with risedronate alone; and R + K group (n = 50), treated with risedronate and vitamin K2. Serum ucOC, OC and incidence of vertebral fractures were evaluated before treatment and at 6 and 12 months post-treatment. Decreased ucOC rates at 6 and 12 months were not significant between groups. However, at 6 and 12 months, decreased OC rates in the R group (p < 0.01 and 0.05, respectively) were significantly higher than in the R + K group, and ucOC/OC change rates in the R group (p < 0.05 and 0.001, respectively) were significantly lower than in the R + K group. Vertebral fracture incidence was not significantly different between the groups at 6 and 12 months. ucOC levels in patients with incident vertebral fractures were significantly higher than in patients without incident vertebral fractures in the R group at 6 months (p < 0.05). Although no significant difference was observed for ucOC decrease rate and incidence of vertebral fractures between treatments, ucOC levels in patients with incident vertebral fractures were significantly greater than in patients without when using risedronate alone.

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Acknowledgments

The authors thank Mrs. Kunihiko Tozawa and Toshiyuki Yuasa (EIDIA Co., Ltd., Tokyo, Japan) for discussion on the measurement of ucOC and OC. The authors also thank Ms. Toshiko Nagasawa for clinical support at the outpatient clinic in Kakunodate General Hospital. The essence of this manuscript was presented at the 29th annual meeting of the Japanese Society for Bone and Mineral Research and selected for an IOF-ANZBMS Travel Award.

Conflict of interest

All authors have no conflicts of interest.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan

    Yuji Kasukawa, Naohisa Miyakoshi, Michio Hongo, Koji Nozaka, Yoshinori Ishikawa, Hidetomo Saito, Shuichi Chida & Yoichi Shimada

  2. Department of Orthopedic Surgery, Kakunodate General Hospital, Senboku, 010-0394, Japan

    Toshihito Ebina & Toshiaki Aizawa

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  1. Yuji Kasukawa
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  2. Naohisa Miyakoshi
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Correspondence to Yuji Kasukawa.

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Kasukawa, Y., Miyakoshi, N., Ebina, T. et al. Effects of risedronate alone or combined with vitamin K2 on serum undercarboxylated osteocalcin and osteocalcin levels in postmenopausal osteoporosis. J Bone Miner Metab 32, 290–297 (2014). https://doi.org/10.1007/s00774-013-0490-5

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  • DOI: https://doi.org/10.1007/s00774-013-0490-5

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