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Effects of growth hormone on bone modeling and remodeling in hypophysectomized young female rats: a bone histomorphometric study

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An Editorial Expression of Concern to this article was published on 10 November 2021

A Correction to this article was published on 27 July 2019

This article has been updated

Abstract

Growth hormone (GH) deficiency causes decreased bone mineral density and osteoporosis, predisposing to fractures. We investigated the mechanism of action of GH on bone modeling and remodeling in hypophysectomized (HX) female rats. Thirty female Sprague–Dawley rats at age 2 months were divided into three groups with 10 rats each: control (CON) group, HX group, and HX + GH (3 mg/kg daily SC) group, for a 4-week study. Hypophysectomy resulted in cessation of bone growth and decrease in cancellous bone mass. Periosteal bone formation decreased and bone turnover rate of endocortical and trabecular surfaces increased as compared to the CON group. GH administration for 4 weeks restored weight gain and bone growth and mitigated decrease in bone density after hypophysectomy. However, trabecular bone mass in the proximal tibial metaphysis remained lower in group HX + GH than in group CON. Dynamic histomorphometric analysis showed that bone modeling of periosteal bone formation and growth plate elongation was significantly higher in group HX + GH than in group HX. New bone formed beneath the growth plate was predominately woven bone in group CON and group HX + GH. Bone remodeling and modeling–remodeling mixed modes in the endocortical and PTM sites were enhanced by GH administration; both bone formation and resorption activities were significantly higher than in group HX. In conclusion, GH administration to HX rats reactivated modeling activities in modeling predominant sites and increased new bone formation. GH administration also increases remodeling activities in remodeling predominant sites, giving limited net gain in the bone mass.

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Change history

  • 27 July 2019

    The following corrections are found in the original publication of the article and corrected as below:

  • 27 July 2019

    The following corrections are found in the original publication of the article and corrected as below:

  • 10 November 2021

    An Editorial Expression of Concern to this paper has been published: https://doi.org/10.1007/s00774-021-01285-4

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Authors and Affiliations

  1. Department of Pediatric Endocrinology, Winthrop University Hospital, 120 Professional Building Suite 210, Mineola, NY, 11501, USA

    Lysette Iglesias & Mariano Castro-Magana

  2. Applied Bench Core Laboratory, Winthrop University Hospital, Mineola, NY, 11501, USA

    James K. Yeh & John F. Aloia

  3. The Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY, 11794, USA

    James K. Yeh & John F. Aloia

Authors
  1. Lysette Iglesias
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  2. James K. Yeh
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  3. Mariano Castro-Magana
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  4. John F. Aloia
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Correspondence to Lysette Iglesias.

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Iglesias, L., Yeh, J.K., Castro-Magana, M. et al. Effects of growth hormone on bone modeling and remodeling in hypophysectomized young female rats: a bone histomorphometric study. J Bone Miner Metab 29, 159–167 (2011). https://doi.org/10.1007/s00774-010-0210-3

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  • DOI: https://doi.org/10.1007/s00774-010-0210-3

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