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Elektrische Zigaretten – Stand der Forschung aus gefäßmedizinischer Sicht

Electric cigarettes: state of research from a vascular medicine perspective

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Literatur

  1. Alzahrani T, Pena I, Temesgen N, Glantz SA (2018) Association between electronic cigarette use and myocardial infarction. Am J Prev Med 55:455–461. https://doi.org/10.1016/J.AMEPRE.2018.05.004

    Article  PubMed  PubMed Central  Google Scholar 

  2. Anand SS (2017) Smoking: a dual pathogen for arterial and venous thrombosis. Circulation 135:17–20. https://doi.org/10.1161/CIRCULATIONAHA.116.025024

    Article  PubMed  Google Scholar 

  3. Anderson C, Majeste A, Hanus J, Wang S (2016) E‑cigarette aerosol exposure induces reactive oxygen species, DNA damage, and cell death in vascular endothelial cells. Toxicol Sci 154:332–340. https://doi.org/10.1093/TOXSCI/KFW166

    Article  CAS  PubMed  Google Scholar 

  4. Barrington-Trimis JL, Leventhal AM (2018) Adolescents’ use of „pod mod“ E‑cigarettes—urgent concerns. N Engl J Med 379:1099–1102. https://doi.org/10.1056/NEJMP1805758

    Article  PubMed  PubMed Central  Google Scholar 

  5. Barua RS, Ambrose JA (2013) Mechanisms of coronary thrombosis in cigarette smoke exposure. Arterioscler Thromb Vasc Biol 33:1460–1467. https://doi.org/10.1161/ATVBAHA.112.300154

    Article  CAS  PubMed  Google Scholar 

  6. Berlowitz JB, Xie W, Harlow AF et al (2022) E‑cigarette use and risk of cardiovascular disease: a longitudinal analysis of the PATH study (2013–2019). Circulation 145:1557–1559. https://doi.org/10.1161/CIRCULATIONAHA.121.057369

    Article  PubMed  Google Scholar 

  7. Biondi-Zoccai G, Sciarretta S, Bullen C et al (2019) Acute effects of heat-not-burn, electronic vaping, and traditional tobacco combustion cigarettes: the Sapienza university of rome-vascular assessment of Proatherosclerotic effects of smoking (SUR – VAPES) 2 randomized trial. J Am Heart Assoc. https://doi.org/10.1161/JAHA.118.010455

    Article  PubMed  PubMed Central  Google Scholar 

  8. Breland A, Soule E, Lopez A et al (2017) Electronic cigarettes: what are they and what do they do? Ann N Y Acad Sci 1394:5–30. https://doi.org/10.1111/NYAS.12977

    Article  PubMed  Google Scholar 

  9. Chaumont M, de Becker B, Zaher W et al (2018) Differential effects of E‑cigarette on microvascular endothelial function, arterial stiffness and oxidative stress: a randomized crossover trial. Sci Rep. https://doi.org/10.1038/S41598-018-28723-0

    Article  PubMed  PubMed Central  Google Scholar 

  10. Chironi GN, Boulanger CM, Simon A et al (2009) Endothelial microparticles in diseases. Cell Tissue Res 335:143–151. https://doi.org/10.1007/S00441-008-0710-9

    Article  PubMed  Google Scholar 

  11. Csordas A, Bernhard D (2013) The biology behind the atherothrombotic effects of cigarette smoke. Nat Rev Cardiol 10:219–230. https://doi.org/10.1038/NRCARDIO.2013.8

    Article  CAS  PubMed  Google Scholar 

  12. Pressemitteilung der Deutschen Gesellschaft für Gefäßchirurgie und Gefäßmedizin e.V. (DGG) (2022) Studien zeigen: E‑Zigaretten unterstützen die Rauchentwöhnung DGG-Experten: elektronische Verbrenner für starke Raucher effektiver als Nikotintherapie. https://www.gefaesschirurgie.de/fileadmin/user_upload/pm1_dgg_online-pk_e-zigaretten_rauchentw%C3%B6hnung_oktober_2022_f_webseite.pdf

  13. Eurobarometer survey (2021) Attitudes of Europeans towards tobacco and electronic cigarettes. https://europa.eu/eurobarometer/surveys/detail/2240. Zugegriffen: 8. Dez. 2022

  14. Fadus MC, Smith TT, Squeglia LM (2019) The rise of e‑cigarettes, pod mod devices, and JUUL among youth: factors influencing use, health implications, and downstream effects. Drug Alcohol Depend 201:85–93. https://doi.org/10.1016/J.DRUGALCDEP.2019.04.011

    Article  PubMed  PubMed Central  Google Scholar 

  15. Farsalinos KE, Polosa R, Cibella F, Niaura R (2019) Is e‑cigarette use associated with coronary heart disease and myocardial infarction? Insights from the 2016 and 2017 national health interview surveys. Ther Adv Chronic Dis. https://doi.org/10.1177/2040622319877741

    Article  PubMed  PubMed Central  Google Scholar 

  16. Fetterman JL, Weisbrod RM, Feng B et al (2018) Flavorings in tobacco products induce endothelial cell dysfunction. Arterioscler Thromb Vasc Biol 38:1607–1615. https://doi.org/10.1161/ATVBAHA.118.311156

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Franzen KF, Willig J, Cayo Talavera S et al (2018) E‑cigarettes and cigarettes worsen peripheral and central hemodynamics as well as arterial stiffness: a randomized, double-blinded pilot study. Vasc Med 23:419–425. https://doi.org/10.1177/1358863X18779694

    Article  PubMed  Google Scholar 

  18. Gali K, Kastaun S, Pischke CR, Kotz D (2022) Trends and consumption patterns in the use of e‑cigarettes among adolescents and young adults in Germany (the DEBRA study). Addict Behav. https://doi.org/10.1016/J.ADDBEH.2022.107375

    Article  PubMed  Google Scholar 

  19. Gonzalez JE, Cooke WH (2021) Acute effects of electronic cigarettes on arterial pressure and peripheral sympathetic activity in young nonsmokers. Am J Physiol Heart Circ Physiol 320:H248–H255. https://doi.org/10.1152/AJPHEART.00448.2020

    Article  CAS  PubMed  Google Scholar 

  20. Hahn J, Monakhova YB, Hengen J et al (2014) Electronic cigarettes: overview of chemical composition and exposure estimation. Tob Induc Dis. https://doi.org/10.1186/S12971-014-0023-6

    Article  PubMed  PubMed Central  Google Scholar 

  21. Hajek P, Phillips-Waller A, Przulj D et al (2019) A randomized trial of E‑cigarettes versus nicotine-replacement therapy. N Engl J Med 380:629–637. https://doi.org/10.1056/NEJMOA1808779

    Article  PubMed  Google Scholar 

  22. Hartmann-Boyce J, McRobbie H, Butler AR et al (2021) Electronic cigarettes for smoking cessation. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD010216.PUB6

    Article  PubMed  PubMed Central  Google Scholar 

  23. Ikonomidis I, Vlastos D, Kourea K et al (2018) Electronic cigarette smoking increases arterial stiffness and oxidative stress to a lesser extent than a single conventional cigarette. Circulation 137:303–306. https://doi.org/10.1161/CIRCULATIONAHA.117.029153

    Article  PubMed  Google Scholar 

  24. Kuntic M, Oelze M, Steven S et al (2020) Short-term e‑cigarette vapour exposure causes vascular oxidative stress and dysfunction: evidence for a close connection to brain damage and a key role of the phagocytic NADPH oxidase (NOX-2). Eur Heart J 41:2472–2483A. https://doi.org/10.1093/EURHEARTJ/EHZ772

    Article  CAS  PubMed  Google Scholar 

  25. Li J, Huynh L, Cornwell WD et al (2021) Electronic cigarettes induce mitochondrial DNA damage and trigger TLR9 (toll-like receptor 9)-mediated atherosclerosis. Arterioscler Thromb Vasc Biol 41:839–853. https://doi.org/10.1161/ATVBAHA.120.315556

    Article  CAS  PubMed  Google Scholar 

  26. Lyytinen G, Bryndal A, Anesäter E et al (2021) Electronic cigarettes containing nicotine increase thrombotic activity and impair microcirculation. Eur Respir J 58:OA2576. https://doi.org/10.1183/13993003.CONGRESS-2021.OA2576

    Article  Google Scholar 

  27. Malas M, van der Tempel J, Schwartz R et al (2016) Electronic cigarettes for smoking cessation: a systematic review. Nicotine Tob Res 18:1926–1936. https://doi.org/10.1093/NTR/NTW119

    Article  PubMed  Google Scholar 

  28. Mobarrez F, Antoniewicz L, Hedman L et al (2020) Electronic cigarettes containing nicotine increase endothelial and platelet derived extracellular vesicles in healthy volunteers. Atherosclerosis 301:93–100. https://doi.org/10.1016/J.ATHEROSCLEROSIS.2020.02.010

    Article  CAS  PubMed  Google Scholar 

  29. Mohammadi L, Han DD, Xu F et al (2022) Chronic E‑cigarette use impairs endothelial function on the physiological and cellular levels. Arterioscler Thromb Vasc Biol 42:1333–1350. https://doi.org/10.1161/ATVBAHA.121.317749

    Article  CAS  PubMed  Google Scholar 

  30. Moheimani RS, Bhetraratana M, Peters KM et al (2017) Sympathomimetic effects of acute E‑cigarette use: role of nicotine and non-nicotine constituents. J Am Heart Assoc. https://doi.org/10.1161/JAHA.117.006579

    Article  PubMed  PubMed Central  Google Scholar 

  31. Mulorz J, Spin JM, Mulorz P et al (2022) E‑cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1. Cardiovasc Res. https://doi.org/10.1093/CVR/CVAC173

    Article  PubMed  Google Scholar 

  32. Nocella C, Biondi-Zoccai G, Sciarretta S et al (2018) Impact of tobacco versus electronic cigarette smoking on platelet function. Am J Cardiol 122:1477–1481. https://doi.org/10.1016/J.AMJCARD.2018.07.029

    Article  CAS  PubMed  Google Scholar 

  33. Nyboe J, Jensen G, Appleyard M, Schnohr P (1991) Smoking and the risk of first acute myocardial infarction. Am Heart J 122:438–447. https://doi.org/10.1016/0002-8703(91)90997-V

    Article  CAS  PubMed  Google Scholar 

  34. Polosa R, Cibella F, Caponnetto P et al (2017) Health impact of E‑cigarettes: a prospective 3.5-year study of regular daily users who have never smoked. Sci Rep. https://doi.org/10.1038/S41598-017-14043-2

    Article  PubMed  PubMed Central  Google Scholar 

  35. Putzhammer R, Doppler C, Jakschitz T et al (2016) Vapours of US and EU market leader electronic cigarette brands and liquids are cytotoxic for human vascular endothelial cells. PLoS One. https://doi.org/10.1371/JOURNAL.PONE.0157337

    Article  PubMed  PubMed Central  Google Scholar 

  36. Ramirez JEM, Karim ZA, Alarabi AB et al (2020) The JUUL E‑cigarette elevates the risk of thrombosis and potentiates platelet activation. J Cardiovasc Pharmacol Ther 25:578–586. https://doi.org/10.1177/1074248420941681

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. https://register.awmf.org/de/leitlinien/detail/076-006. Zugegriffen: 1. Dez. 2022

  38. Rom O, Pecorelli A, Valacchi G, Reznick AZ (2015) Are E‑cigarettes a safe and good alternative to cigarette smoking? Ann N Y Acad Sci 1340:65–74. https://doi.org/10.1111/NYAS.12609

    Article  CAS  PubMed  Google Scholar 

  39. Shinton R, Beevers G (1989) Meta-analysis of relation between cigarette smoking and stroke. BMJ 298:789–794. https://doi.org/10.1136/BMJ.298.6676.789

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Szparaga M, Świercz R, Stępnik M (2021) Review of data on chemical content in an aerosol resulting from heating a tobacco or a solution used in e‑cigarettes and in the smoke generated from the reference cigarettes. Toxicol Mech Methods 31:323–333. https://doi.org/10.1080/15376516.2021.1884922

    Article  CAS  PubMed  Google Scholar 

  41. Vlachopoulos C, Aznaouridis K, Stefanadis C (2010) Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol 55:1318–1327. https://doi.org/10.1016/J.JACC.2009.10.061

    Article  PubMed  Google Scholar 

  42. Vlachopoulos C, Ioakeimidis N, Abdelrasoul M et al (2016) Electronic cigarette smoking increases aortic stiffness and blood pressure in young smokers. J Am Coll Cardiol 67:2802–2803. https://doi.org/10.1016/j.jacc.2016.03.569

    Article  PubMed  Google Scholar 

  43. Voos N, Goniewicz ML, Eissenberg T (2019) What is the nicotine delivery profile of electronic cigarettes? Expert Opin Drug Deliv 16:1193–1203. https://doi.org/10.1080/17425247.2019.1665647

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Wagener TL, Floyd EL, Stepanov I et al (2017) Have combustible cigarettes met their match? The nicotine delivery profiles and harmful constituent exposures of second-generation and third-generation electronic cigarette users. Tob Control 26:e23–e28. https://doi.org/10.1136/tobaccocontrol-2016-053041

    Article  PubMed  Google Scholar 

  45. Yan XS, D’Ruiz C (2015) Effects of using electronic cigarettes on nicotine delivery and cardiovascular function in comparison with regular cigarettes. Regul Toxicol Pharmacol 71:24–34. https://doi.org/10.1016/J.YRTPH.2014.11.004

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Klinik für Gefäß- und Endovaskularchirurgie, Universitätsklinikum Düsseldorf, Merowingerstraße 5, 40225, Düsseldorf, Deutschland

    Sönke Maximilian Braß,  Markus Udo Wagenhäuser,  Florian Simon,  Hubert Schelzig &  Joscha Mulorz

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Correspondence to Joscha Mulorz.

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S. Braß, M.U. Wagenhäuser, F. Simon, H. Schelzig und J. Mulorz geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Braß, S.M., Wagenhäuser, M.U., Simon, F. et al. Elektrische Zigaretten – Stand der Forschung aus gefäßmedizinischer Sicht. Gefässchirurgie 28, 140–144 (2023). https://doi.org/10.1007/s00772-023-00974-w

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