Abstract
Perinatal psychological stress has been associated with unfavorable maternal and neonatal outcomes. We aimed to assess the impact of perinatal stress on infant development at 1 year of age. We recruited pregnant women calling North American Teratogen Information Services or attending outpatient clinics at CHU Sainte Justine (Montreal) between 2008 and 2010 and their spouses. To be part of our study, women had to be (1) >18 years of age, (2) <15 weeks of gestational age at recruitment, (3) living within 250-km radius of Montreal, and (4) taking antidepressants or non-teratogenic drugs. Stress was assessed using the telephone-administered four-item perceived stress scale during pregnancy in mothers and at 2 months postpartum in both parents. Child development at 1 year of age was evaluated with the Bayley III scales. Socio-demographic and potential confounders were collected through telephone interviews. Multivariable linear regression models were built to assess the association between perinatal parental stress and child development. Overall, 71 couples and their infants were included. When adjusted for potential confounders, maternal prenatal stress was positively associated with motor development (adjusted β = 1.85, CI 95 % (0.01, 3.70)). Postpartum maternal and paternal stresses were negatively associated with motor and socio-emotional development, respectively (adjusted β = −1.54, CI 95 % (−3.07, −0.01) and adjusted β = −1.67, CI 95 % (−3.25, −0.10), respectively). Maternal and paternal postnatal stress seems to be harmful for the motor and socio-emotional development in 1-year-old children. No association was demonstrated between parental stress and cognitive, language, and adaptive behavioral development. However, prenatal maternal stress appears to improve motor skills.
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References
Abbott A, Bartlett D (1999) The relationship between the home environment and early motor development. Phys Occup Ther Pediatr 19(1):43–57
Abidin R (1995). Parenting stress index professional manual, psychological assessment resources
Anthony LG, Anthony BJ, Glanville DN et al (2005) The relationships between parenting stress, parenting behaviour and preschoolers’ social competence and behaviour problems in the classroom. Infant Child Dev 14:133–154
Austin MP, Leader L (2000) Maternal stress and obstetric and infant outcomes: epidemiological findings and neuroendocrine mechanisms. Aust N Z J Psychiatry 40(3):331–337
Austin PC, Steyerberg EW (2015) The number of subjects per variable required in linear regression analyses. J Clin Epidemiol 68(6):627–636
Bayley N (2006a) Bayley scales of infant and toddler development. The Psychological Corporation, San Antonio
Bayley N (2006b) Bayley scales of infant and toddler development, 3rd Ed.: administration manual. Harcourt Assessment, San Antonio
Bergink V, Kooistra L, Lambregtse-van den Berg MP et al (2011) Validation of the Edinburgh depression scale during pregnancy. J Psychosom Res 70(4):385–389
Carey WB, Crocker AC, Roy Elias E et al (2009) Developmental screening and assessment. Developmental-behavioral pediatrics. Saunders, Philadelphia, pp 747–846
Carmichael SL, Shaw GM (2000) Maternal life event stress and congenital anomalies. Epidemiology 11(1):30–35
Casper RC, Gilles AA, Fleisher BE et al (2011) Length of prenatal exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants: effects on neonatal adaptation and psychomotor development. Psychopharmacology 217(2):211–219
Chaaya M, Osman H, Naassan G et al (2010) Validation of the arabic version of the Cohen perceived stress scale (PSS-10) among pregnant and postpartum women. BMC Psychiatr 10:111
Class QA, Lichtenstein P, Langstrom N et al (2011) Timing of prenatal maternal exposure to severe life events and adverse pregnancy outcomes: a population study of 2.6 million pregnancies. Psychosom Med 73(3):234–241
Cohen S, Williamson G (1988). Perceived stress in a probability sample of the U.S. The Social Psychology of Health. S. S. S. Oskamp. Newbury Park, CA, Sage. 13: 31–67
Cox JL, Holden JM, Sagovsky R (1987) Detection of postnatal depression. Development of the 10-item Edinburgh postnatal depression scale. Brit J Psychiatr 150:782–786
Crnic KA, Gaze C, Hoffman C (2005) Cumulative parenting stress across the preschool period: relations to maternal parenting and child behavior at age 5. Infant Child Dev 14:117–132
Culp RE, Schadle S, Robinson L et al (2000) Relationships among paternal involvement and young children’s perceived self-competence and behavioral problems. J Child Fam Stud 9:27–38
Darke PR, Goldberg S (1994) Father-infant interaction and parent stress with healthy and medically compromised infants. Infant Behav Dev 17(1):3–14
Davis EP, Sandman CA (2010) The timing of prenatal exposure to maternal cortisol and psychosocial stress is associated with human infant cognitive development. Child Dev 81(1):131–148
Deater-Deckard K, Scarr S (1996) Parenting stress among dual-earner mothers and fathers: are there gender differences? J Fam Psychol 10(1):45–59
Diamond M, Hopson J (1998) Magic trees of the mind: how to nurture your child’s intelligence, creativity, and healthy emotions from birth through adolescence. Dutton, New York
DiPietro JA, Novak MF, Costigan KA et al (2006) Maternal psychological distress during pregnancy in relation to child development at age two. Child Dev 77(3):573–587
Downer J, Campos R, McWayne C et al (2008) Father involvement and children’s early learning: a critical review of published empirical work from the past 15 years. Marriage Fam Rev 43(1–2):67–108
Dunkel Schetter C, Tanner L (2012) Anxiety, depression and stress in pregnancy: implications for mothers, children, research, and practice. Curr Opin Psychiatry 25(2):141–148
Eberhard-Gran M, Eskild A, Tambs K et al (2001) Review of validation studies of the Edinburgh postnatal depression scale. Acta Psychiatr Scand 104(4):243–249
Elsenbruch S, Benson S, Rucke M et al (2007) Social support during pregnancy: effects on maternal depressive symptoms, smoking and pregnancy outcome. Hum Reprod 22(3):869–877
Essex MJ, Boyce WT, Hertzman C et al (2013) Epigenetic vestiges of early developmental adversity: childhood stress exposure and DNA methylation in adolescence. Child Dev 84(1):58–75
Fagan J, Lee Y (2014) Longitudinal associations among fathers’ perception of coparenting, partner relationship quality, and paternal stress during early childhood. Fam Process 53(1):80–96
Figueredo VM (2009) The time has come for physicians to take notice: the impact of psychosocial stressors on the heart. Am J Med 122(8):704–712
Fujioka T, Fujioka A, Tan N et al (2001) Mild prenatal stress enhances learning performance in the non adopted rat offspring. Neuroscience 103(2):301–307
Gallois T, Wendland J (2012/3). Effets du stress prénatal sur le développement cognitif et psychoaffectif de l’enfant: une revue de la question. Méd Hyg Dev 24: 245–262
Gibson CS, MacLennan AH, Goldwater, PN et al (2003) Antenatal causes of cerebral palsy: associations between inherited thrombophilias, viral and bacterial infection, and inherited susceptibility to infection. Obstet Gynecol Surv 58(3):209–220
Giesbrecht GF, Campbell T, Letourneau N et al (2012) Psychological distress and salivary cortisol covary within persons during pregnancy. Psychoneuroendocrinology 37(2):270–279
Giesbrecht GF, Poole JC, Letourneau N et al (2013) The buffering effect of social support on hypothalamic-pituitary-adrenal axis function during pregnancy. Psychosom Med 75(9):856–862
Glascoe FP (2003) Parents’ evaluation of developmental status: how well do parents’ concerns identify children with behavioral and emotional problems? Clin Pediatr 42:133–138
Glover V (2014) Maternal depression, anxiety and stress during pregnancy and child outcome; what needs to be done. Best Pract Res Clin Obstet Gynaecol 28(1):25–35
Glynn LM, Schetter CD, Hobel CJ et al (2008) Pattern of perceived stress and anxiety in pregnancy predicts preterm birth. Health Psychol 27(1):43–51
Hanley GE, Brain U, Oberlander TF (2013) Infant developmental outcomes following prenatal exposure to antidepressants, and maternal depressed mood and positive affect. Early Hum Dev 89(8):519–524
Karam F, Berard A, Sheehy O et al (2012) Reliability and validity of the 4-item perceived stress scale among pregnant women: results from the OTIS antidepressants study. Res Nurs Health 35(4):363–375
Keim SA, Daniels JL, Dole N et al (2011) A prospective study of maternal anxiety, perceived stress, and depressive symptoms in relation to infant cognitive development. Early Hum Dev 87(5):373–380
Kendler KS, Thornton LM, Gardner CO. (2000) Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the “kindling” hypothesis. Am J Psychiatry 157(8):1243–1251
Khashan AS, Abel KM, McNamee R et al (2008) Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events. Arch Gen Psychiatry 65(2):146–152
Kingston D, Heaman M, Fell D et al (2012) Factors associated with perceived stress and stressful life events in pregnant women: findings from the Canadian Maternity Experiences Survey. Matern Child Health J 16(1):158–168
Kleinhaus K, Harlap S, Perrin M et al (2013) Prenatal stress and affective disorders in a population birth cohort. Bipolar Disord 15(1):92–99
Knickmeyer RC, Gouttard S, Kang C et al (2008) A structural MRI study of human brain development from birth to 2 years. J Neurosci 28(47):12176–12182
Koleck M, Quintard B, Tastets S (2002) French validation of the perceived stress scale: the construct validity. European Health Psychology Society-16th Conference
Kutner MH, Nachtsheim CJ, Neter J et al (2004) Applied linear regression models, 4th edn. McGraw-Hill/Irwin, New York
Laplante DP, Brunet A, Schmitz, N et al (2008) Project ice storm: prenatal maternal stress affects cognitive and linguistic functioning in 5 1/2-year-old children. J Am Acad Child Adolesc Psychiatry 47(9):1063–1072
Lazarus RS, Folkman S (1984) Stress, appraisal, and coping. Springer, New York
LeWinn KZ, Stroud LR, Molnar BE et al (2009) Elevated maternal cortisol levels during pregnancy are associated with reduced childhood IQ. Int J Epidemiol 38(6):1700–1710
Lobel M, Dunkel-Schetter C, Scrimshaw SC (1992) Prenatal maternal stress and prematurity: a prospective study of socioeconomically disadvantaged women. Health Psychol 11(1):32–40
Lovallo WR (1997) Stress and health: biological and psychological interactions. Sage Publication, Thousands Oaks
Magill-Evans J, Harrison MJ (2001) Parent–child interactions, parenting stress, and developmental outcomes at 4 years. Child Health Care 30:135–150
Mantymaa M, Luoma I, Salmelin R et al (2003) Infant-mother interaction as a predictor of child’s chronic health problems. Child Care Health Dev 29(3):181–191
Mitchell AM, Crane PA, Kim Y (2008) Perceived stress in survivors of suicide: psychometric properties of the perceived stress scale. Res Nurs Health 31(6):576–585
Mitchell-DiCenso A, Guyatt G, Paes B et al (1996) A new measure of parent satisfaction with medical care provided in the neonatal intensive care unit. J Clin Epidemiol 49(3):313–318
Murray L, Carothers AD (1990) The validation of the Edinburgh post-natal depression scale on a community sample. Br J Psychiatry 157:288–290
Murray D, Cox JL (1990) Screening for depression during pregnancy with the Edinburgh postnatal depression scale (EPDS). J Reprod Infant Psychol 8(2):99–107
O’Donnell K, O'Connor TG, Glover V (2009) Prenatal stress and neurodevelopment of the child: focus on the HPA axis and role of the placenta. Dev Neurosci 31(4):285–292
O’Hara MW (2009) Postpartum depression: what we know. J Clin Psychol 65(12):1258–1269
O’Neil ME, Palisano RJ, Westcott SL (2001) Relationship of therapists’ attitudes, children’s motor ability, and parenting stress to mothers’ perceptions of therapists’ behaviors during early intervention. Phys Ther 81(8):1412–1424
Parke RD (1996) Fatherhood. Harvard University Press, Cambridge
Paykel ES, Dowlatshahi D (1988). Life events and mental disorder. Handbook of life stress, cognition and health: 241–263
Pettit GS, Brown EG, Mize J et al (1998) Mothers’ and fathers’ socializingbehaviors in three contexts: links with children’s peer competence. Merrill Palmer Q 44:173–193
Phillips AC (2013). Perceived stress. Encyclopedia of behavioral medicine. Gellman MD, Turner JR. Springer New York: 1453–1454
Pop VJ, Komproe IH, van Son MJ (1992) Characteristics of the Edinburgh postnatal depression scale in the Netherlands. J Affect Disord 26(2):105–110
Pridham KF, Brown R, Clark R et al (2002) Infant and caregiving factors affecting weight-for-age and motor development of full-term and premature infants at 1 year post-term. Res Nurs Health 25(5):394–410
Pruett K, Litzenburger B (1992) Latency development in children of primary nurturing fathers: eight-year follow-up. Psychoanal Study Child 4:85–90
Rao K (2009) Recent research in stress, coping and women’s health. Cur Opin Psychiatry 22(2):188–193
Roggman LA, Boyce KA, Cook GA et al (2002) Getting dads involved: predictors of father involvement in early head start and with children. Infant Ment Health J 23(1–2):62–78
Saisto T, Salmela-Aro K, Nurmi JE et al (2008) Longitudinal study on the predictors of parental stress in mothers and fathers of toddlers. J Psychosom Obstet Gynaecol 29(3):213–222
Sarkadi A, Kristiansson R, Oberklaid F et al (2008) Fathers’ involvement and children’s developmental outcomes: a systematic review of longitudinal studies. Acta Paediatr 97(2):153–158
Schmid B, Blomeyer D, Buchmann AF et al (2011) Quality of early mother-child interaction associated with depressive psychopathology in the offspring: a prospective study from infancy to adulthood. J Psychiatr Res 45(10):1387–1394
Scott Ricci S, Kyle T (2009). Growth and development of the newborn and infant. Maternity and pediatric nursing. Lippincott Williams & Wilkins: 769–797
Statistics Canada (2013) Stress and well-being. http://www.statcan.gc.ca/pub/82-625-x/2014001/article/14023-eng.htm
Wadhwa PD, Sandman CA, Porto M et al (1993) The association between prenatal stress and infant birth weight and gestational age at birth: a prospective investigation. Am J Obstet Gynecol 169(4):858–865
Welberg LA, Seckl JR (2001) Prenatal stress, glucocorticoids and the programming of the brain. J Neuroendocrinol 13(2):113–128
Whiteside-Mansell L, Ayoub C, McKelvey L et al (2007) Parenting stress of low-income parents of toddlers and preschoolers: psychometric properties of a short form of the parenting stress index. Parent Sci Pract 7:27–56
Wittmer DS, Peterson SH, Puckett MB (2000) The young child: development from prebirth through age eight. Prentice-Hall, Inc, Upper Saddle River
Yogman M (1981) Games fathers and mothers play with their infants. Infant Ment Health J 2:241–248
Zhu P, Tao F, Hao J et al (2010) Prenatal life events stress: implications for preterm birth and infant birthweight. Am J Obstet Gynecol 203(1):34.e31-38
Acknowledgments
We thank each OTIS center and the research nurses for the recruitment of participants and the CIHR-Quebec Training Network in Perinatal Research for the student scholarship. This study was supported by the Canadian Institutes of Health Research (CIHR, grant number IHD-79787), the “Fonds de la recherche en santé du Quebec” (FRSQ), and the “Conseil du medicament.” Dr. Anick Bérard is the recipient of a career award from the FRSQ and is on the endowment Research Chair of the Famille Louis-Boivin on Medications, Pregnancy, and Lactation at the Faculty of Pharmacy at the University of Montreal.
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Karam, F., Sheehy, O., Huneau, MC. et al. Impact of maternal prenatal and parental postnatal stress on 1-year-old child development: results from the OTIS antidepressants in pregnancy study. Arch Womens Ment Health 19, 835–843 (2016). https://doi.org/10.1007/s00737-016-0624-6
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DOI: https://doi.org/10.1007/s00737-016-0624-6