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Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation

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Abstract

Aloin, a natural anthracycline from aloe plant, is a hydroxyanthraquinone derivative shown to have antitumor properties. This study demonstrated that aloin exerted inhibition of cell proliferation, adhesion and invasion abilities of B16-F10 melanoma cells under non-cytotoxic concentrations. Furthermore, aloin induced melanoma cell differentiation through the enhancement of melanogenesis and transglutaminase activity. To improve the growth-inhibiting effect of anticancer agents, we found that the combined treatment of cells with aloin and low doses of cisplatin increases the antiproliferative activity of aloin. The results suggest that aloin possesses antineoplastic and antimetastatic properties, exerted likely through the induction of melanoma cell differentiation.

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Acknowledgments

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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Authors and Affiliations

  1. Department of Biology, University “Tor Vergata”, Via della Ricerca Scientifica, 00133, Rome, Italy

    Claudio Tabolacci, Alessandro Lentini, Bruno Provenzano, Lorenzo Turcano & Simone Beninati

  2. Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

    Stefania Rossi & Francesco Facchiano

Authors
  1. Claudio Tabolacci
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  2. Stefania Rossi
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  3. Alessandro Lentini
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  4. Bruno Provenzano
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  5. Lorenzo Turcano
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  6. Francesco Facchiano
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  7. Simone Beninati
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Corresponding author

Correspondence to Claudio Tabolacci.

Additional information

C. Tabolacci and S. Rossi contributed equally to this work.

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Tabolacci, C., Rossi, S., Lentini, A. et al. Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation. Amino Acids 44, 293–300 (2013). https://doi.org/10.1007/s00726-011-1166-x

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  • DOI: https://doi.org/10.1007/s00726-011-1166-x

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