Skip to main content
SpringerLink
Log in

Optische Kohärenztomographie der Photorezeptorschicht im gesunden Auge und bei hereditärer Makuladystrophie

Optical coherence tomography of the photoreceptor layer in the healthy eye and in eyes with hereditary macular dystrophy

  • Originalarbeiten
  • Published:
Spektrum der Augenheilkunde Aims and scope Submit manuscript

Zusammenfassung

Die optische Kohärenztomographie wird heute vor allem zur Darstellung grober Abweichungen der Netzhautarchitektur, wie bei Makulaloch, epiretinaler Gliose, intra- und subretinalen Flüssigkeitsansammlungen und retinaler Atrophie verwendet. Bei Anwendung höher auflösender OCT-Geräte können auch diskrete Veränderungen der Photorezeptorschicht und des Pigmentepithels dargestellt werden. An Hand von Fällen mit zwei verschiedenartigen hereditären Makuladystrophien wird gezeigt, welche Bedeutung die Beurteilung der Photorezeptorschicht hat und wie diese mit den Visuswerten korreliert.

Summary

Optical coherence tomography is primarily used for the evaluation of pronounced alterations of the retinal architecture, such as in macular holes, epiretinal gliosis, intra- and subretinal fluid accumulation as well as retinal atrophy. Ultrahigh resolution OCT devices also allow the assessment of discrete alterations of the photoreceptor layer and the retinal pigment epithelium. On the basis of cases from two different macular dystrophies, the importance of the evaluation of the photoreceptor layer and its correlation with visual acuity is demonstrated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  • Huang D, Swanson EA, Lin CP, et al (1991) Optical coherence tomography. Science 254 (5035): 1178–1181

    Article  PubMed  CAS  Google Scholar 

  • Fercher AF, Hitzenberger CK, Drexler W, et al (1993) In vivo optical coherence tomography. Am J Ophthalmol 116 (1): 113–114

    PubMed  CAS  Google Scholar 

  • Schuman JS, Hee MR, Puliafito CA, et al (1995) Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography. Arch Ophthalmol 113 (5): 586–596

    PubMed  CAS  Google Scholar 

  • Schuman JS, Hee MR, Arya AV, et al (1995) Optical coherence tomography: a new tool for glaucoma diagnosis. Curr Opin Ophthalmol 6 (2): 89–95

    PubMed  CAS  Google Scholar 

  • Puliafito CA, Hee MR, Lin CP, et al (1995) Imaging of macular diseases with optical coherence tomography. Ophthalmology 102 (2): 217–229

    PubMed  CAS  Google Scholar 

  • Hee MR, Puliafito CA, Wong C, et al (1995) Optical coherence tomography of central serous chorioretinopathy. Am J Ophthalmol 120 (1): 65–74

    PubMed  CAS  Google Scholar 

  • Hee MR, Puliafito CA, Wong C, et al (1995) Optical coherence tomography of macular holes. Ophthalmology 102 (5): 748–756

    PubMed  CAS  Google Scholar 

  • Baumgartner A, Hitzenberger CK, Ergun E, et al (2000) Resolution-improved dual-beam and standard optical coherence tomography: a comparison. Graefes Arch Clin Exp Ophthalmol 238 (5): 385–392

    Article  PubMed  CAS  Google Scholar 

  • Drexler W, Sattmann H, Hermann B, et al (2003) Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography. Arch Ophthalmol 121 (5): 695–706

    Article  PubMed  Google Scholar 

  • Schmidt-Erfurth U, Leitgeb RA, Michels S, et al (2005) Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases. Invest Ophthalmol Vis Sci 46 (9): 3393–3402

    Article  PubMed  Google Scholar 

  • Stargardt KB (1909) Über familiäre progressive Degeneration in der Makulagegend des Auges. Albrecht V Graefes Arch Ophthalmol 71: 534–550

    Google Scholar 

  • Lois N, Halfyard AS, Bird AC, et al (2004) Fundus autofluorescence in Stargardt macular dystrophy-fundus flavimaculatus. Am J Ophthalmol 138 (1): 55–63

    Article  PubMed  Google Scholar 

  • Rivera A, White K, Stohr H, et al (2000) A comprehensive survey of sequence variation in the ABCA4 (ABCR) gene in Stargardt disease and age-related macular degeneration. Am J Hum Genet 67 (4): 800–813

    Article  PubMed  CAS  Google Scholar 

  • Gass JD (1974) A clinicopathologic study of a peculiar foveomacular dystrophy. Trans Am Ophthalmol Soc 72: 139–156

    PubMed  CAS  Google Scholar 

  • Best F (1905) Über eine hereditäre Maculaaffektion. Z Augenheilkd 13: 199–212

    Google Scholar 

  • Battaglia Parodi M, Iustulin D, Russo D, et al (1996) Adult-onset foveomacular vitelliform dystrophy and indocyanine green videoangiography. Graefes Arch Clin Exp Ophthalmol 234 (3): 208–211

    Article  PubMed  CAS  Google Scholar 

  • Barr DB, Beirouty ZA (1995) Autofluorescence in a patient with adult vitelliform degeneration. Eur J Ophthalmol 5 (3): 155–159

    PubMed  CAS  Google Scholar 

  • Renner AB, Tillack H, Kraus H, et al (2004) Morphology and functional characteristics in adult vitelliform macular dystrophy. Retina 24 (6): 929–939

    Article  PubMed  Google Scholar 

  • Ergun E, Hermann B, Wirtitsch M, et al (2005) Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci 46 (1): 310–316

    Article  PubMed  Google Scholar 

  • Wirtitsch MG, Ergun E, Hermann B, et al (2005) Ultrahigh resolution optical coherence tomography in macular dystrophy. Am J Ophthalmol 140 (6): 976–983

    Article  PubMed  Google Scholar 

  • Gloesmann M, Hermann B, Schubert C, et al (2003) Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci 44 (4): 1696–1703

    Article  PubMed  Google Scholar 

  • Hittner HM, Ferrell RE, Borda RP, et al (1984) Atypical vitelliform macular dystrophy in a 5-generation family. Br J Ophthalmol 68 (3): 199–207

    PubMed  CAS  Google Scholar 

  • Eksandh L, Ekstrom U, Abrahamson M, et al (2001) Different clinical expressions in two families with Stargardt's macular dystrophy (STGD1). Acta Ophthalmol Scand 79 (5): 524–530

    Article  PubMed  CAS  Google Scholar 

  • Spaide RF, Noble K, Morgan A, et al (2006) Vitelliform macular dystrophy. Ophthalmology 113 (8): 1392–1400

    Article  PubMed  Google Scholar 

  • Pierro L, Tremolada G, Introini U, et al (2002) Optical coherence tomography findings in adult-onset foveomacular vitelliform dystrophy. Am J Ophthalmol 134 (5): 675–680

    Article  PubMed  Google Scholar 

  • Cruz-Villegas V, Villate N, Knighton RW, et al (2003) Optical coherence tomographic findings in acute exudative polymorphous vitelliform maculopathy. Am J Ophthalmol 136 (4): 760–763

    Article  PubMed  Google Scholar 

  • Benhamou N, Messas-Kaplan A, Cohen Y, et al (2004) Adult-onset foveomacular vitelliform dystrophy with OCT 3. Am J Ophthalmol 138 (2): 294–296

    Article  PubMed  Google Scholar 

  • Hargitai J, Zernant J, Somfai GM, et al (2005) Correlation of clinical and genetic findings in Hungarian patients with Stargardt disease. Invest Ophthalmol Vis Sci 46 (12): 4402–4408

    Article  PubMed  Google Scholar 

  • Samsel A, Drobecka-Brydak E, Brydak-Godowska J, et al (2005) Optical coherence tomography in Stargardt's dystrophy. Klin Oczna 107 (10–12): 668–671

    PubMed  Google Scholar 

  • Querques G, Leveziel N, Benhamou N, et al (2006) Analysis of retinal flecks in fundus flavimaculatus using optical coherence tomography. Br J Ophthalmol 90 (9): 1157–1162

    Article  PubMed  CAS  Google Scholar 

  • Ko TH, Fujimoto JG, Schuman JS, et al (2005) Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology. Ophthalmology 112 (11): 1922

    Article  PubMed  Google Scholar 

  • Fernandez EJ, Povazay B, Hermann B, et al (2005) Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using a liquid crystal spatial light modulator. Vision Res 45 (28): 3432–3444

    Article  PubMed  Google Scholar 

  • Wojtkowski M, Srinivasan V, Fujimoto JG, et al (2005) Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography. Ophthalmology 112 (10): 1734–1746

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Augenheilkunde und Optometrie, Medizinische Universität Wien, Austria

    M. Stur

  2. Zentrum Biomedizinische Technik und Physik, Medizinische Universität Wien, Austria

    B. Hermann, A. Unterhuber, H. Sattmann & W. Drexler

  3. Department of Optometry and Vision Sciences, University of Cardiff, Wales, UK

    B. Hermann, A. Unterhuber & W. Drexler

  4. Augenabteilung, Sanatorium Hera, Wien, Austria

    E. Ergun

  5. Augenabteilung, KH Wien-Hietzing, Austria

    M. Wirtitsch

Authors
  1. M. Stur
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Hermann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Ergun
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Unterhuber
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Wirtitsch
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. Sattmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. W. Drexler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Stur.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stur, M., Hermann, B., Ergun, E. et al. Optische Kohärenztomographie der Photorezeptorschicht im gesunden Auge und bei hereditärer Makuladystrophie. Spektrum Augenheilkd. 21, 29–32 (2007). https://doi.org/10.1007/s00717-006-0170-0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00717-006-0170-0

Schlüsselwörter

Key words

Search

Navigation