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The Synthesis of Novel Methotrexate-like Compounds

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Summary.

Methotrexate (MTX) is a folate antagonist used in treatment of several chronic inflammatory and neoplastic conditions. In this study, new MTX-like compounds that may-be potential anticancer agents were synthesized and their structures were determined by IR, UV, GC-MS, 1H NMR, and 13C NMR spectra. Also, in this study, a series structurally related to MTX or folate analogous compounds were evaluated whether they have inhibitory properties on the dihydrofolate reductase activity (DHFR).

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science and Arts, Gazi University, Ankara, Turkey

    Naki Çolak & Yılmaz Yıldırır

  2. Department of Medical Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey

    Mustafa Kavutcu & Nilhan Nurlu

Authors
  1. Naki Çolak
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  2. Yılmaz Yıldırır
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  3. Mustafa Kavutcu
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  4. Nilhan Nurlu
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Corresponding author

Correspondence to Yılmaz Yıldırır.

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Çolak, N., Yıldırır, Y., Kavutcu, M. et al. The Synthesis of Novel Methotrexate-like Compounds. Monatsh. Chem. 138, 1283–1287 (2007). https://doi.org/10.1007/s00706-007-0716-0

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  • DOI: https://doi.org/10.1007/s00706-007-0716-0

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